Results 91 to 100 of about 458,745 (304)

Electrical current-driven pinhole formation and insulator-metal transition in tunnel junctions

open access: yes, 2007
Current Induced Resistance Switching (CIS) was recently observed in thin tunnel junctions (TJs) with ferromagnetic (FM) electrodes and attributed to electromigration of metallic atoms in nanoconstrictions in the insulating barrier. The CIS effect is here
J B Sousa   +9 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The Influence of Seamounts on the Enrichment of Rare Earth Elements in Sediments—A Case Study of the Marcus-Wake Seamounts in the Western Pacific Ocean

open access: yesJournal of Marine Science and Engineering
Deep-sea sediments enriched in rare earth elements and yttrium (REY-rich sediments) are widely distributed on the deep-sea floor, and their formation mechanism remains elusive.
Tinglu Xiao   +8 more
doaj   +1 more source

Physical Sources of High‐Frequency Seismic Noise on Cascadia Initiative Ocean Bottom Seismometers

open access: yesGeochemistry, Geophysics, Geosystems, 2020
Physical sources of high‐frequency seismic noise in the ocean are investigated using data from the Cascadia Initiative (CI) ocean bottom seismometer (OBS) network, hindcasts of wind speed, waves, and the bottom currents predicted by a regional ocean ...
Rose Hilmo, William S. D. Wilcock
doaj   +1 more source

Fluid flow near reservoir lakes inferred from the spatial and temporal analysis of the electric potential [PDF]

open access: yes, 2002
Electric self-potential (SP) variations have been monitored continuously from 1995 to 1998 at 14 points on a ridge separating the Roselend and La Gittaz reservoir lakes in the French Alps.
Avouac, Jean-Philippe   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Methane release from the southern Brazilian margin during the last glacial

open access: yesScientific Reports, 2018
Seafloor methane release can significantly affect the global carbon cycle and climate. Appreciable quantities of methane are stored in continental margin sediments as shallow gas and hydrate deposits, and changes in pressure, temperature and/or bottom ...
R. C. Portilho-Ramos   +10 more
doaj   +1 more source

The present state of the water exchange through the Strait of Gibraltar [PDF]

open access: yes, 2015
The present two-way exchange through the Strait of Gibraltar stems from the fresh water deficit of the Mediterranean basin. The size of the exchanged flows is the outcome of the climatology over the basin and the morphology and internal hydraulics of the
García-Lafuente, Jesús
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Interacting Fermionic Atoms in Optical Lattices Diffuse Symmetrically Upwards and Downwards in a Gravitational Potential

open access: yes, 2011
We consider a cloud of fermionic atoms in an optical lattice described by a Hubbard model with an additional linear potential. While homogeneous interacting systems mainly show damped Bloch oscillations and heating, a finite cloud behaves differently: It
Mandt, Stephan, Rapp, Akos, Rosch, Achim
core   +1 more source

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