Results 71 to 80 of about 458,745 (304)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Hybrid turbidite–contourite systems in the modern Tarakan Basin: seismic sedimentology and analogue for subsurface storage

Frontiers in Earth Science
Hybrid turbidite–contourite systems are present where gravity-driven and bottom-current processes interact. Although recent studies have advanced our understanding, deciphering the relative roles of downslope and alongslope processes in shaping the deep ...
Harya Dwi Nugraha, Harya Dwi Nugraha, Hade Bakda Maulin   +2 more
doaj   +1 more source

Flavor-Safe Light Squarks in Higgs-Anomaly Mediation

, 2018
We consider a simple setup with light squarks which is free from the gravitino and SUSY flavor problems. In our setup, a SUSY breaking sector is sequestered from the matter and gauge sectors, and it only couples to the Higgs sector directly with ...
Yanagida, Tsutomu T., Yin, Wen, Yokozaki, Norimi   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The role of Internal Solitary Waves on deep-water sedimentary processes. The case of up-slope migrating sediment waves off the Messina Strait [PDF]

, 2016
Subaqueous, asymmetric sand waves are typically observed in marine channel/canyon systems, tidal environments, and continental slopes exposed to strong currents, where they are formed by current shear resulting from a dominant unidirectional flow ...
Casalbore, Daniele, Chiocci, Francesco, Droghei, Riccardo, Falcini, Federico, Martorelli, Eleonora, Mosetti, Renzo, Salusti, Ettore, Sannino, Gianmaria, Santoleri, Rosalia   +8 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Observations of the Vertical Structure of Tidal Currents in Two Inlets [PDF]

, 2013
Observations of the vertical structure of broad band tidal currents were obtained at two energetic inlets. Each experiment took place over a 4 week period, the first at Hampton Inlet in southeastern New Hampshire, USA, in the Fall of 2011, and the second
Hunt, Jonathan, Irish, James D, Lippmann, Thomas C.   +2 more
core   +2 more sources

ON THE IMPROVEMENT OF THE TILTING BOTTOM CURRENT METER

Journal of Oceanological Research, 2019
The article describes the advanced design of Tilt Current Meter (TCM), developed in the Shirshov Institute of Oceanology. This type of meters is used in recent years mainly in Western countries due to low cost, ease of manufacture and the possibility of replication.
V. T. Paka, V. N. Nabatov, A. A. Kondrashov, A. O. Korzh, A. P. Podufalov, S. D. Obleukhov, M. N. Golenko, S. A. Shchuka   +7 more
openaire   +2 more sources