Results 171 to 180 of about 16,499 (205)
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Delivery of single-domain antibodies into neurons using a chimeric toxin–based platform is therapeutic in mouse models of botulism

Science Translational Medicine, 2021
A detoxified chimeric toxin–based platform delivers therapeutics into neurons and has therapeutic effects in mouse models of botulism. Nontoxic botulinum for drug delivery Botulism is a severe and potentially fatal disease characterized by muscle ...
Shin-Ichiro Miyashita   +4 more
semanticscholar   +1 more source

Infant botulism: an underestimated threat

Infectious Diseases, 2021
Infant botulism (IB) is defined as a potentially life-threatening neuroparalytic disorder affecting children younger than 12 months. It is caused by ingestion of food or dust contaminated by Clostridium botulinum spores, which germinate in the infant’s ...
Luca Antonucci   +4 more
semanticscholar   +1 more source

Safety and Clinical Outcomes of an Equine-Derived Heptavalent Botulinum Antitoxin Treatment for Confirmed or Suspected Botulism in the United States.

Clinical Infectious Diseases, 2020
BACKGROUND Botulism is a rare, life-threatening paralytic illness. BAT® [Botulism Antitoxin Heptavalent (A,B,C,D,E,F,G)-(Equine)] is an equine-derived heptavalent botulinum antitoxin product indicated for the treatment of symptomatic botulism following ...
Jason S Richardson   +6 more
semanticscholar   +1 more source

Botulism

Clinical Infectious Diseases, 2005
Botulism is a rare disease with 4 naturally occurring syndromes: foodborne botulism is caused by ingestion of foods contaminated with botulinum toxin, wound botulism is caused by Clostridium botulinum colonization of a wound and in situ toxin production, infant botulism is caused by intestinal colonization and toxin production, and adult intestinal ...
openaire   +2 more sources

Lambert-Eaton Myasthenic Syndrome, Botulism, and Immune Checkpoint Inhibitor-Related Myasthenia Gravis.

Continuum, 2019
PURPOSE OF REVIEW This article reviews the pathophysiology, epidemiology, clinical presentation, diagnosis, and treatment of Lambert-Eaton myasthenic syndrome (LEMS) and of botulism, and immune-related myasthenia gravis (MG) occurring in the context of ...
A. Guidon
semanticscholar   +1 more source

Botulism in China

Clinical Infectious Diseases, 1986
During the period 1958-1983, 986 outbreaks of botulism occurred in China, affecting 4,377 individuals and resulting in 548 deaths. The initial cases of botulism were found in Xinjiang province, where the incidence was highest. Outbreaks have occurred in all of the northern provinces and in some of the southern provinces of China.
Shih Ying, Chao Shuyan
openaire   +3 more sources

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