Results 61 to 70 of about 1,323,303 (307)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Of Negotiable Boundaries and Fixed Lines in Borneo: Practices and Views of the Border in the Apo Kayan Region of East Kalimantan

Moussons, 2007
The paper focuses on borders and boundaries as practiced, perceived, changed, and enforced by different actors in the Apo Kayan region, an isolated plateau in the interior of Indonesian Borneo at the border with Sarawak (Malaysia).
Cristina Eghenter
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Using Action Research to Organize Technology Transfer in Complex Innovation Contexts

Technology Innovation Management Review, 2019
Technology transfer projects increasingly consist of multiple, diverse organizations, with each pursuing their own agenda as well as that of the overarching programme.
Armando Machevo Ussivane, Paul Ellwood
doaj   +1 more source

Managing across knowledge boundaries

, 2017
This chapter discusses the implications of knowledge specialization in relation to five types of knowledge boundaries (individual, domain-specific, task-oriented, spatial, and temporal), and mechanisms that potentially could be used to bridge these ...
Tell, Fredrik,
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Maintaining the Complex Personal and Professional Elements of Our Lives in Academe

Journal of Communication Pedagogy
This reflective essay offers several practical suggestions for scholars and professionals who are looking for ways to sustain abundant personal and professional lives in a discipline that encourages workaholic tendencies and requires many to engage in ...
Sydney E. Brammer, Ryan J. Martinez, Narissra M. Punyanunt-Carter   +2 more
doaj   +1 more source

Optimal boundaries for decisions [PDF]

In this paper we state and prove some new results about the optimal boundaries. These boundaries (also called Pareto boundaries or efficiency boundaries or maximal/minimal boundaries) are of increasing importance in the applications to Decision Theory ...
Carfì, David
core  

Preceptorship rural boundaries: Student perspective [PDF]

, 2007
This is one part of a grounded theory study that explored the perceptions of both students and preceptors regarding the student-preceptor relationship in a rural setting and the boundaries that must be developed to ensure it is successful. The success of
Yonge, O.
core   +1 more source