Results 71 to 80 of about 1,323,303 (307)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Space and Sonship: Paul’s Familial Metaphors in Rom 8
ReligionsPaul often uses metaphors as a method of persuasion. In Rom 8, Paul’s use of kinship metaphors such as “sonship” and being “heirs” is particularly ubiquitous.
Annette Potgieter
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Rezkova věcnost a její techniky
Filosofický časopisThe essay reconstructs the notion of “matter-of-factness” (Sachlichkeit, věcnost) in Petr Rezek’s philosophy and its roots in the immanence of our experience – or more precisely, in the tension generated by two requirements that are bound to it: (1) the ...
Kolman, Vojtěch
doaj +1 more source
Introduction: Managing knowledge integration across boundaries
, 2017 In a world characterized by increasing knowledge specialization, managing knowledge integration across boundaries constitutes a key challenge for organizations.
Tell, Fredrik, +3 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Vulnerable Bodies and Embodied Boundaries
, 2016 A body, and especially a body considered as a whole, is a mass distinct from other masses. It occupies space, and as a geometric figure, it is three-dimensional having length, breadth, and thickness. Its dimensions and its weight can be measured. To be a
Folkmarson Käll, Lisa, +1 more
core +1 more source