Results 61 to 70 of about 23,352 (256)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Development and Application of Two-Dimensional Numerical Tank using Desingularized Indirect Boundary Integral Equation Method

open access: yes한국해양공학회지, 2018
In this study, a two-dimensional fully nonlinear transient wave numerical tank was developed using a desingularized indirect boundary integral equation method.
Seunghoon Oh   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

A Cauchy integral method to solve the 2D Dirichlet and Neumann problems for irregular simply-connected domains

open access: yesУчёные записки Казанского университета: Серия Физико-математические науки, 2018
A method for construction of solutions to the continuous approximate 2D Dirichlet and Neumann problems in the arbitrary simply-connected domain with a smooth boundary has been discussed.
A. El-Shenawy, E.A. Shirokova
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Efficient Analysis of Compact Vias in an Arbitrarily Shaped Plate Pair by Hybrid Boundary-Integral and Finite-Element Method

open access: yesIEEE Access, 2019
The hybrid boundary-integral equation and finite-element method (BIE/FEM) is efficient for signal/power integrity analysis of multiple vias in a shared antipad (labeled as compact vias) in an arbitrarily shaped power/ground plate pair. According to field
Xinxin Tian   +6 more
doaj   +1 more source

On the Boundary-Domain Integral Equation Method for the Dirichlet Problem of the Compressible Stokes System with Variable Viscosity

open access: yes, 2020
We derive two systems of boundary-domain integral equations (BDIEs) equivalent to the Dirichlet problem for the compressible Stokes system using the potential method with an explicit parametrix (Levi function). The BDIEs are given in terms of surface and volume hydrodynamic potentials.
Dagnaw, M. A., Fresneda-Portillo, C.
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Boundary domain integral method for high Reynolds viscous fluid flows in complex planar geometries

open access: yesComputer Methods in Applied Mechanics and Engineering, 2005
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hriberšek, Matjaž, Škerget, Leopold
openaire   +2 more sources

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