Results 91 to 100 of about 1,930,507 (291)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Mittag-Leffler Stabilization of an Unstable Time Fractional Hyperbolic PDE

IEEE Access, 2019
This paper aims to study the Mittag-Leffler stabilization of an unstable time fractional hyperbolic partial differential equation by boundary control and boundary measurement.
Chunwan Lv, Huacheng Zhou, Feiqi Deng
doaj   +1 more source

Boundary control for a class of dissipative differential operators including diffusion systems [PDF]

, 2006
In this paper we study a class of partial differential equations (PDE's), which includes Sturm-Liouville systems and diffusion equations. From this class of PDE's we define systems with control and observation through the boundary of the spatial domain ...
Le Gorrec, Y., Maschke, B.M., Villegas, J.A., Yamamoto, Y, Zwart, Heiko J.   +4 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Optimal control problems for nonlinear parabolic boundary control systems: the Dirichlet boundary condition

Differential and Integral Equations, 1994
A boundary control system described by a semilinear partial differential heat equation is considered. The control is applied through the forced Dirichlet boundary condition. The optimal control problem is that of minimizing a cost functional among all determined admissible controls for which the corresponding solutions satisfy a given target condition.
Fattorini, H. O., Murphy, T.
openaire   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Exact boundary controllability for higher order nonlinear Schrodinger equations with constant coefficients

Electronic Journal of Differential Equations, 2005
The exact boundary controllability of the higher order nonlinear Schrodinger equation with constant coefficients on a bounded domain with various boundary conditions is studied.
Juan Carlos Ceballos V., Ricardo Pavez F., Octavio Paulo Vera V.   +2 more
doaj  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Passivity-based boundary control with the backstepping observer for the vibration suppression of the flexible beam. [PDF]

Heliyon, 2023
Boonkumkrong N, Chinvorarat S, Asadamongkon P.   +2 more
europepmc   +1 more source