Results 81 to 90 of about 404,554 (315)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Boundary element formulations for the numerical solution of two-dimensional diffusion problems with variable coefficients [PDF]
, 2012 This is the post-print version of the final paper published in Computers & Mathematics with Applications. The published article is available from the link below.
Škerget, L +7 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
A boundary control problem for the pure Cahn-Hilliard equation with dynamic boundary conditions [PDF]
, 2015 A boundary control problem for the pure Cahn–Hilliard equations with possibly singular potentials and dynamic boundary conditions is studied and first-order necessary conditions for optimality are ...
Sprekels, Jürgen +3 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Numerical simulation of boundary-layer control using MEMS actuation [PDF]
MEMS actuators and their effect on boundary layers is investigated using numerical simulation. The thesis is specifically focussed on jet actuators and their application to the targeted control of turbulent boundary layers.
Lockerby, Duncan A.
core
The Application of Optimal Control to Boundary Layer Flow
, 2006 Modern optimal control theory can be used to calculate the optimal steady suction needed to e.g. relaminarize the flow or to delay transition. This has been used to devise the best possible suction distributions for keeping the flow laminar, and applied ...
D. S. Henningson +3 more
core +1 more source
A Boundary Control Problem for the Viscous Cahn–Hilliard Equation with Dynamic Boundary Conditions [PDF]
, 2014 A boundary control problem for the viscous Cahn–Hilliard equations with possibly singular potentials and dynamic boundary conditions is studied and first order necessary conditions for optimality are ...
Sprekels, Jürgen +3 more
core +1 more source
Boundary Control by Boundary Observer for Hyper-redundant Robots
International Journal of Computers Communications & Control, 2010 The control problem of a class of hyper-redundant arms with continuum elements, with boundary measuring and control is discussed. First, the dynamic model of the continuum arm is presented. The measuring systems are based on the film sensors that are placed at the terminal sub-regions of the arm.
Mircea Ivanescu +6 more
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source