Results 81 to 90 of about 1,930,507 (291)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Boundary stabilization and control of wave equations by means of a general multiplier method
, 2009 We describe a general multiplier method to obtain boundary stabilization of the wave equation by means of a (linear or quasi-linear) Neumann feedback. This also enables us to get Dirichlet boundary control of the wave equation.
Cornilleau, Pierre, Loheac, Jean-Pierre
core +1 more source
Event-triggered gain scheduling of reaction-diffusion PDEs
, 2020 This paper deals with the problem of boundary stabilization of 1D reaction-diffusion PDEs with a time- and space- varying reaction coefficient. The boundary control design relies on the backstepping approach.
Espitia, Nicolas +2 more
core
Optimal Control of the Multiphase Stefan Problem
, 2017 We consider the inverse multiphase Stefan problem, where information on the heat flux on the fixed boundary is missing and must be found along with the temperature and free boundaries. Optimal control framework is pursued, where boundary heat flux is the
Abdulla, Ugur G., Poggi, Bruno
core +1 more source
Controlled Boundary and h-Cobordism Theorems [PDF]
Transactions of the American Mathematical Society, 1983 In this paper two theorems are established which are consequences of some earlier approximation results of the author. The first theorem is a controlled boundary theorem for finite-dimensional manifolds. By this we mean an ordinary boundary theorem plus small ε \varepsilon -control in a given parameter space.
openaire +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Fractal and FractionalThis study is devoted to solving the global Mittag-Leffler synchronization problem of fractional-order fuzzy reaction–diffusion inertial neural networks by using boundary control.
Lianyang Hu +5 more
doaj +1 more source