Results 61 to 70 of about 1,481,716 (292)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Boundary crossing for international opportunities

, 2015
In this introductory article, we discuss international opportunities in international entrepreneurship as a particular phenomenon that focuses on boundary crossing.
Mainela, Tuija, Puhakka, Vesa, Servais, Per   +2 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Beyond single domains: Writing in boundary crossing [PDF]

, 2014
The chapter explains the role of text production in intellectual, cultural, and social mobility in a digital age. Written communication is becoming increasingly important across the domains, where in order to produce text people must cross boundaries ...
Oakey, David, Russell, David
core  

Lighthouse as a transdisciplinary boundary-crossing learning innovation

, 2023
The Lighthouse was a learning activity that offered entrepreneurship pedagogy outside the academic structures of higher education, in a religious context, and among grassroots practitioners.
Woods, Christine, Steve Taylor, Johnston, Mark, Taylor, Steve, Christine Woods, Mark Johnston   +5 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Broadening Perspectives on Broadening Participation: Professional Learning Tools for More Expansive and Equitable Science Communication

Frontiers in Communication, 2020
Many professionals in the field of science communication have argued that our work too often tends to be designed for people like ourselves—those already interested in, comfortable with, and engaged with science.
Bronwyn Bevan, Angela Calabrese Barton, Cecilia Garibay   +2 more
doaj   +1 more source

Boundary Crossing Support in Part-Time Higher Professional Education Programs [PDF]

, 2020
As learning societies necessitate continuous education, a growing number of part-time programs are being offered. A key challenge for part-time programs is adequately supporting students in connecting their learning within the program to their work life,
Bronkhorst, Larike H., Arts, Margit, Education and Learning: Development in Interaction, Leerstoel Akkerman   +3 more
core  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source