Results 91 to 100 of about 1,402,818 (287)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Investigation of a boundary simulation of continuity using the discrete solid element method
Advances in Mechanical Engineering, 2019 The discrete solid element method is an efficient numerical method that simulates the large deformation, strong material nonlinearity, fracture, and dynamic problems of continuity.
Baochen Zhu, Ruoqiang Feng
doaj +1 more source
Analysis of arching around shallow tunnels using the boundary element approach [PDF]
, 2010 This paper describes a study of the effect of soil arching around shallow tunnels using the Boundary Element Method. Due to the different stiffnesses of the soil and the underground structure, then, under surface loading, the differential displacements ...
Davies, T.G., Kamchoom, V.
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Applications of FEM and BEM in two-dimensional fracture mechanics problems [PDF]
A comparison of the finite element method (FEM) and boundary element method (BEM) for the solution of two-dimensional plane strain problems in fracture mechanics is presented in this paper.
Min, J. B. +2 more
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The Global Element Method for Three- Dimensional Potential Problems
IEEE AccessThis paper presents the Global Element Method (GEM) for solving three-dimensional potential problems. Compared to traditional boundary element methods, this approach offers significant advantages.
Xinrong Li, Chao Zhang, Yaoming Zhang
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Engineering Transactions, 2014 An initial stability of Kirchhoff plates is analysed in the paper. Proposed approach avoids Kirchhoff forces at the plate corner and equivalent shear forces at a plate boundary. Two unknown variables are considered at the boundary element node.
Michał GUMINIAK
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Shape optimization of three-dimensional stamped and solid automotive components [PDF]
The shape optimization of realistic, 3-D automotive components is discussed. The integration of the major parts of the total process: modeling, mesh generation, finite element and sensitivity analysis, and optimization are stressed.
Bennett, J. A. +2 more
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