Results 101 to 110 of about 1,402,818 (287)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The boundary element method - a review

open access: yesJournal of Numerical Analysis and Approximation Theory, 1981
Not available.
H. M. Semple
doaj   +2 more sources

ANALISA ELASTISITAS DENGAN BOUNDARY ELEMENT

open access: yesMedia Mesin, 2016
Dalam tulisan ini, analisa elastisitas dengan  boundary element method disampaikan. Perumusan-perumusan boundary element method juga diperkeknalkan. Untuk menyelesaikan persamaan yang didapatkan integrasi numerik diterapkan.
Supriyono Supriyono
doaj  

Static and free vibration analysis of thin plates of the curved edges by the Boundary Element Method considering an alternative formulation of boundary conditions

open access: yesEngineering Transactions, 2016
A static and dynamic analysis of Kirchhoff plates is presented in this paper. The proposed approach avoids Kirchhoff forces at the plate corners and equivalent shear forces at a plate boundary. Two unknown variables are considered at the boundary element
Michał Jan GUMINIAK
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

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