Results 111 to 120 of about 1,402,818 (287)

Adaptive FE-BE coupling for strongly nonlinear transmission problems with friction II

, 2013
This article discusses the well-posedness and error analysis of the coupling of finite and boundary elements for transmission or contact problems in nonlinear elasticity.
Gimperlein, Heiko, Stephan, Ernst P.
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

APPLYING BOUNDARY ELEMENT METHOD TO SOLVE THE HEAT CONDUCTION PROBLEMS USING CONSTANT ELEMENT

Journal of Engineering and Sustainable Development, 2015
In this work two-dimensional boundary element method (BEM) using constant element is mathematically and numerically investigated and applied to solve differential equations of the heat conduction problems and temperature distribution of solid bodies to ...
Saad Najeeb Shehab
doaj  

A method for magnetocardiography functional localization based on boundary element method and Nelder-Mead simplex algorithm. [PDF]

Ann Noninvasive Electrocardiol, 2021
Lu Z, Jiang D, Yang J.
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Boundary element fast multipole method for modeling electrical brain stimulation with voltage and current electrodes. [PDF]

J Neural Eng, 2021
Makarov SN, Golestanirad L, Wartman WA, Nguyen BT, Noetscher GM, Ahveninen JP, Fujimoto K, Weise K, Nummenmaa AR.   +8 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Boundary Element Fast Multipole Method for Enhanced Modeling of Neurophysiological Recordings. [PDF]

IEEE Trans Biomed Eng, 2021
Makarov SN, Hamalainen M, Okada Y, Noetscher GM, Ahveninen J, Nummenmaa A.   +5 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Sensitivity analysis of non-uniform rational B-splines–based finite element/boundary element coupling in structural-acoustic design

Frontiers in Physics
For the purpose of modeling the acoustic fluid-structure interaction using direct differentiation method and conducting a structural-acoustic sensitivity analysis, a coupling approach based on the finite element method and the fast multipole boundary ...
Yanming Xu, Sen Yang, Sen Yang
doaj   +1 more source