Results 81 to 90 of about 1,397,215 (290)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
علوم آب و خاک, 2019 Seismic study of canyon sites has always been one of the important fields of seismic studies because of massive structures such as dams that are built in such sites.
M. Zabardast, F. Daneshvar Vousoughi
doaj
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Investigation of a boundary simulation of continuity using the discrete solid element method
Advances in Mechanical Engineering, 2019 The discrete solid element method is an efficient numerical method that simulates the large deformation, strong material nonlinearity, fracture, and dynamic problems of continuity.
Baochen Zhu, Ruoqiang Feng
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Calculation of low frequency vibrational resonances of submerged structures [PDF]
Numerical techniques for calculating the low frequency vibrational resonances of submerged structures are reviewed. Both finite element and boundary element approaches for calculating fully-coupled added mass matrices for use in NASTRAN analysis are ...
Everstine, Gordon C.
core +1 more source
Helmholtz solver with transparent influx boundary conditions and nonuniform exterior [PDF]
, 2007 Boundary conditions for a 2D finite element Helmholtz solver are derived, which allow scattered light to leave the calculation domain in the presence of outgoing waveguides.
Groesen, E. van +3 more
core +4 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The boundary element method - a review
Journal of Numerical Analysis and Approximation Theory, 1981 Not available.
H. M. Semple
doaj +2 more sources