Results 31 to 40 of about 1,137,944 (246)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A Computational Model for Nonlinear Biomechanics Problems of FGA Biological Soft Tissues

Applied Sciences, 2022
The principal objective of this work was to develop a semi-implicit hybrid boundary element method (HBEM) to describe the nonlinear fractional biomechanical interactions in functionally graded anisotropic (FGA) soft tissues.
Mohamed Abdelsabour Fahmy
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

BOUNDARY ELEMENT METHOD

Rudarsko-geološko-naftni Zbornik, 1993
This paper includes main theses, proofs, and procedures of Boundary Element Method (BEM). The computer program. announced in 1981, for the calculation of stresses and strains around underground opening was used, comprising plane strain state for elastic ...
Mladen Hudec, Lidija Frgić
doaj  

Investigation of a boundary simulation of continuity using the discrete solid element method

Advances in Mechanical Engineering, 2019
The discrete solid element method is an efficient numerical method that simulates the large deformation, strong material nonlinearity, fracture, and dynamic problems of continuity.
Baochen Zhu, Ruoqiang Feng
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

2D Structural Acoustic Analysis Using the FEM/FMBEM with Different Coupled Element Types

Archives of Acoustics, 2016
A FEM-BEM coupling approach is used for acoustic fluid-structure interaction analysis. The FEM is used to model the structure and the BEM is used to model the exterior acoustic domain.
Leilei CHEN, Wenchang ZHAO, Cheng LIU, Haibo CHEN   +3 more
doaj   +1 more source

A Computational Method for Acoustic Interaction with Large Complicated Underwater Structures Based on the Physical Mechanism of Structural Acoustics

Advances in Materials Science and Engineering, 2022
A numerical coupling approach is proposed to fast predict the acoustic radiation from a vibrating large-complicated underwater structure. In this study, the physical mechanism of sound radiation from underwater large target is used for the first time to ...
Yongzhuang Tang, Qidou Zhou, Xiaowei Wang, Zhiyong Xie   +3 more
doaj   +1 more source

A quadtree-polygon-based scaled boundary finite element method for image-based mesoscale fracture modelling in concrete [PDF]

, 2019
A quadtree-polygon scaled boundary finite element-based approach for image-based modelling of concrete fracture at the mesoscale is developed. Digital images representing the two-phase mesostructure of concrete, which comprises of coarse aggregates and ...
A.A. Saputra, Benkemoun, Bolander, Bruggi, C. Song, Camacho, Cundall, Deeks, Du, D’Addetta, E.H. Ooi, E.T. Ooi, Eláš, Feng, Gerstle, Grassl, H. Guo, Hordijk, Huang, Huang, Huang, Kozicki, Landis, Legrain, Lian, López, Monteiro, Nitka, Ooi, Pan, Reddy, Ren, Rodrigues, Roth, S. Natarajan, Saputra, Schlangen, Schlangen, Shahbazi, Shahbeyk, Skarżyński, Snozzi, Song, Song, Su, Su, Suchorzewski, Tabarraei, Trawiński, Wang, Wang, Wang, Wriggers, Xu, Yaghoobi, Yang, Yang, Young, Z. Yang, Zhang   +59 more
core   +1 more source