Results 151 to 160 of about 215,554 (316)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Chromosome boundary elements and regulation of heterochromatin spreading. [PDF]
Cell Mol Life Sci, 2014 Wang J, Lawry ST, Cohen AL, Jia S.
europepmc +1 more source
Equivariant Preconditioners for Boundary Element Methods
SIAM Journal on Scientific Computing, 1996 The author presents two preconditioners for boundary integral equations on nearly symmetric domains. The first preconditioner is obtained by discretizing the integral equation on a related symmetric domain. The second one is derived by solving a minimization problem.
openaire +3 more sources
Dynamic behavior of frame structures by boundary integral procedures
, 2015 The Boundary Element Method is applied to synthesize a set of Boundary Integral Equations representing the uncoupled axial and flexural dynamic behavior of rectilinear Bernoulli-Euler beam elements in the frequency domain.
Barretto, SFA, Neto, ED, Pavanello, R
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Chromatin boundary elements organize genomic architecture and developmental gene regulation in Drosophila Hox clusters. [PDF]
World J Biol Chem, 2016 Ma Z +7 more
europepmc +1 more source
Fitted meshes on an unfitted grid based on scaled boundary finite element analysis
Traditional domain based discretization techniques (both mesh based and meshless methods), require a conforming discretization to capture the boundary/interfaces present in a structure.
Song, Chongmin +4 more
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source