Results 41 to 50 of about 4,570,639 (247)

Chromosome structure in Drosophila is determined by boundary pairing not loop extrusion

open access: yeseLife
Two different models have been proposed to explain how the endpoints of chromatin looped domains (‘TADs’) in eukaryotic chromosomes are determined.
Xinyang Bing   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Investigation of a boundary simulation of continuity using the discrete solid element method

open access: yesAdvances in Mechanical Engineering, 2019
The discrete solid element method is an efficient numerical method that simulates the large deformation, strong material nonlinearity, fracture, and dynamic problems of continuity.
Baochen Zhu, Ruoqiang Feng
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

An ACA Accelerated isogeometric boundary element analysis of potential problems with non-uniform boundary conditions [PDF]

open access: yes, 2017
This paper presents an Adaptive Cross Approximation (ACA) accelerated Isogeometric Boundary Element Method (IGBEM) using Non-Uniform Rational B-Splines (NURBS) as shape and interpolation functions. Provided that NURBS are used in CAD programs to describe
Campos, LS, Wrobel, LC, Albuquerque, EL
core   +4 more sources

Effects of opening in shear walls of 30- storey building

open access: yesJournal of Materials and Engineering Structures, 2015
Tall towers and multi-storey buildings have fascinated mankind from the beginning of civilization, their construction being initially for defense and subsequently for ecclesiastical purposes.
Ruchi Sharma, Jignesh A Amin
doaj  

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

A Computational Method for Acoustic Interaction with Large Complicated Underwater Structures Based on the Physical Mechanism of Structural Acoustics

open access: yesAdvances in Materials Science and Engineering, 2022
A numerical coupling approach is proposed to fast predict the acoustic radiation from a vibrating large-complicated underwater structure. In this study, the physical mechanism of sound radiation from underwater large target is used for the first time to ...
Yongzhuang Tang   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Adjustment of a turbulent boundary layer to a 'canopy' of roughness elements [PDF]

open access: yes, 2003
A model is developed for the adjustment of the spatially averaged time-mean flow of a deep turbulent boundary layer over small roughness elements to a canopy of larger three-dimensional roughness elements.
Jerram, N   +5 more
core   +1 more source

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