Results 61 to 70 of about 4,570,639 (247)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Metals, 2019 Hydrogen enhanced decohesion is expected to play a major role in ferritic steels, especially at grain boundaries. Here, we address the effects of some common alloying elements C, V, Cr, and Mn on the H segregation behaviour and the decohesion mechanism ...
Aparna P. A. Subramanyam +4 more
doaj +1 more source
Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity. [PDF]
PLoS Genetics, 2011 Genomic maps of chromatin modifications have provided evidence for the partitioning of genomes into domains of distinct chromatin states, which assist coordinated gene regulation.
Meiji Kit-Wan Ma +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Effect of the surface-active elements on grain boundary oxidation of hot-stamped steel
Materials Letters: XThe effects of minor surface-active alloy elements Sb and Sn on hot-stamped steel grain boundary oxidation at different coiling temperatures were studied through tube sealing and soaking.
Y.Y. Ge, Q.L. Cui
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
United States, northern border 1878
, 1878 Index map title: Index map, Joint Series. Shows the United States and Canadian border from the summit of the Rocky Mountains to the northwest angle of the Lake of the Woods. Relief shown by hachures and spot heights. Title from second sheet. First sheet
United States Northern Boundary Commission
core
BOUNDARY ELEMENTS MODELLING FOR SMALL/LARGE STRAIN ANALYSIS OF ELASTOMERIC MATERIALS
Journal of Engineering, 2010 In this paper the boundary elements method is used as numerical techniques for solving elastomeric materials (rubber or rubber-like materials) under small and large strains analysis.
Imad A. Hussain +2 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source