Results 101 to 110 of about 228,192 (267)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

On function families with boundary [PDF]

Pacific Journal of Mathematics, 1962
openaire   +2 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Logarithmic capacity and Riemann and Hilbert problems for generalized analytic functions

Доповiдi Нацiональної академiї наук України
The study of the Dirichlet problem with arbitrary measurable boundary data for harmonic functions in the unit disk is due to the famous Luzin dissertation.
V.Ya. Gutlyanskiĭ, O.V. Nesmelova, V.I. Ryazanov, A.S. Yefimushkin   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

On boundary-value problems for generalized analytic and harmonic functions

Доповiдi Нацiональної академiї наук України
The present paper is a natural continuation of our last articles on the Riemann, Hilbert, Dirichlet, Poincaré, and, in particular, Neumann boundary-value problems for quasiconformal, analytic, harmonic functions and the so-called A-harmonic functions ...
V.Ya. Gutlyanskiĭ, O.V. Nesmelova, V.I. Ryazanov, A.S. Yefimushkin   +3 more
doaj   +1 more source

Boundary functions for functions defined in a disk.

Michigan Mathematical Journal, 1961
Bagemihl, F., Piranian, G.
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Reliable and efficient inverse analysis using physics-informed neural networks with normalized distance functions and adaptive weight tuning

Machine Learning: Science and Technology
Physics-informed neural networks (PINNs) have attracted significant attention in scientific machine learning for their capability to solve forward and inverse problems governed by partial differential equations. However, the accuracy of PINN solutions is
Shota Deguchi, Mitsuteru Asai
doaj   +1 more source

On the Šilov boundary of the vertex function

Communications in Mathematical Physics, 1969
The Silov boundary of the vertex function is computed without resource to analytic completion techniques.
openaire   +2 more sources