Results 91 to 100 of about 593,564 (351)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Boundary Integral Equations - A Personal View
Electronic Journal of Boundary Elements, 2007 My first exposure to what were best known then as potential methods was around the 1965-1966 academic year at the University of Washington in Seattle, Washington. I had been a stress analyst at The Boeing Company, working on the US's version of the Supersonic Transport, which was properly fated for many reasons never to be built and fly.
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Author Correction: Boundary integral equation method for resonances in gradient index cavities designed by conformal transformation optics. [PDF]
Sci Rep, 2021 Ryu JW +7 more
europepmc +1 more source
Integral representation of a solution to the Stokes-Darcy problem [PDF]
, 2015 With methods of potential theory we develop a representation of a solution of the coupled Stokes-Darcy model in a Lipschitz domain for boundary data in H-1 ...
Medková, Dagmar +6 more
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한국해양공학회지, 2018 In this study, a two-dimensional fully nonlinear transient wave numerical tank was developed using a desingularized indirect boundary integral equation method.
Seunghoon Oh +3 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 2012 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The boundary element method (BEM) has become a powerful method for the numerical solution of boundary-value problems (BVPs), due to its ability (at least ...
Al-Jawary, Majeed
core
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source