Results 91 to 100 of about 32,527 (309)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Analysis of two-operator boundary-domain integral equations for variable-coefficient mixed BVP

, 2011
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2011 Steklov Mathematical Institute RAS.Applying the two-operator approach, the mixed (Dirichlet–Neumann) boundary value ...
Mikhailov, SE, Ayele, TG
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Approximate Solution of an Optimal Control Dot Mobile Problem for a Nonlinear Hyperbolic Equation

Моделирование и анализ информационных систем, 2014
In this article, we consider the approximate solution of an optimal control dot mobile problem for a system of nonlinear partial hyperbolic and ordinary differential equations with initial and boundary value conditions and a nonlinear optimality ...
T. K. Yuldashev
doaj   +1 more source

Fractional Langevin Equations with Nonseparated Integral Boundary Conditions

Advances in Mathematical Physics, 2020
In this paper, we discuss the existence of solutions for nonlinear fractional Langevin equations with nonseparated type integral boundary conditions.
Khalid Hilal, Lahcen Ibnelazyz, Karim Guida, Said Melliani   +3 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Localized direct segregated boundary-domain integral equations for variable-coefficient transmission problems with interface crack

, 2011
The full text of the published article can be accessed at the link belowSome transmission problems for scalar second order elliptic partial differential equations are considered in a bounded composite domain consisting of adjacent anisotropic subdomains ...
Mikhailov, SE, Natroshvili, D, Chkadua, O   +2 more
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

System of singular integral equations in the problem of electromagnetic oscillations of a graphene-coated dielectric ball

Известия высших учебных заведений. Поволжский регион: Физико-математические науки
Background. Boundary value transmission problems for a system of Maxwell's equations are fundamental in electrodynamics. Recently, there has been interest in problems involving the presence of a thin layer of graphene on the surface, which changes the ...
Yu.G. Smirnov, O.V. Kondyrev
doaj   +1 more source

High-Order Integral Equation Methods for Diffraction Problems Involving Screens and Apertures [PDF]

, 2012
This thesis presents a novel approach for the numerical solution of problems of diffraction by infinitely thin screens and apertures. The new methodology relies on combination of weighted versions of the classical operators associated with the Dirichlet ...
Lintner, Stéphane Karl
core   +1 more source