Results 71 to 80 of about 3,234,210 (272)

Approximate solution of second kind integral equations on infinite cylindrical surfaces [PDF]

open access: yes, 1994
The paper considers second kind integral equations of the form (abbreviated)φφK+=g, in which S is an infinite cylindrical surface of arbitrary smooth cross-section.
Peplow, AT, Chandler-Wilde, SN
core   +5 more sources

On variational formulations of inner boundary value problems for infinite systems of elliptic equations of special kind [PDF]

open access: yesМатематичні Студії, 2012
We consider boundary value problems for infinite triangular systems of elliptic equations with variable coefficients in 3d Lipschitz domains. Variational formulations of Dirichlet, Neumann and Robin problems are received and their well posedness in ...
Yu. A. Muzychuk, R. S. Chapko
doaj  

A computing method for bending problem of thin plate on Pasternak foundation

open access: yesAdvances in Mechanical Engineering, 2020
The governing equation of the bending problem of simply supported thin plate on Pasternak foundation is degraded into two coupled lower order differential equations using the intermediate variable, which are a Helmholtz equation and a Laplace equation. A
Jiarong Gan   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Numerical solution and spectrum of boundary-domain integral equation for the Neumann BVP with variable coefficient [PDF]

open access: yes, 2012
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 Taylor & Francis.In this paper, a numerical implementation of a direct united boundary-domain integral equation (BDIE ...
Mikhailov, SE, Mohamed, NA
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Rothe's Method for the Heat Equation and Boundary Integral Equations

open access: yesJournal of Integral Equations and Applications, 1997
The paper deals with the exterior initial boundary value problem for the heat equation in two space variables in the finite time interval. Discretizing the time derivative by the Euler backward difference quotient (Rothe's method) a system \((B_n)\) of Dirichlet boundary value problems is obtained.
Chapko, Roman, Kress, Rainer
openaire   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

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