Results 71 to 80 of about 6,521,077 (382)

Generation of Turbulent Inflow Data for Spatially-Developing Boundary Layer Simulations

, 1998
A method for generating three-dimensional, time-dependent turbulent inflow data for simulations of complex spatially developing boundary layers is described. The approach is to extract instantaneous planes of velocity data from an auxiliary simulation of
T. Lund, Xiaohua Wu, K. Squires
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Characteristics and Source Apportionment of Metallic Elements in PM_2.5 at Urban and Suburban Sites in Beijing: Implication of Emission Reduction

Atmosphere, 2019
To gain insights into the impacts of emission reduction measures on the characteristics and sources of trace elements during the 2014 Asia-Pacific Economic Cooperation (APEC) summit, PM2.5 samples were simultaneously collected from an urban site and a ...
Miaoling Li, Zirui Liu, Jing Chen, Xiaojuan Huang, Jingyun Liu, Yuzhu Xie, Bo Hu, Zhongjun Xu, Yuanxun Zhang, Yuesi Wang   +9 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Mixing layer height and its implications for air pollution over Beijing, China [PDF]

Atmospheric Chemistry and Physics, 2016
The mixing layer is an important meteorological factor that affects air pollution. In this study, the atmospheric mixing layer height (MLH) was observed in Beijing from July 2009 to December 2012 using a ceilometer. By comparison with radiosonde data,
G. Tang, J. Zhang, X. Zhu, T. Song, C. Münkel, B. Hu, K. Schäfer, Z. Liu, J. Zhang, L. Wang, J. Xin, P. Suppan, Y. Wang   +12 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

PM2.5 Characteristics and Regional Transport Contribution in Five Cities in Southern North China Plain, During 2013–2015

Atmosphere, 2018
PM2.5 data from major cities in the southern North China Plain during 2013–2015 were comprehensively analyzed relative to variation features, meteorology effects, and regional transport contributions.
Lili Wang, Wenjie Li, Yang Sun, Minghui Tao, Jinyuan Xin, Tao Song, Xingru Li, Nan Zhang, Kang Ying, Yuesi Wang   +9 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Assessing CALIOP-Derived Planetary Boundary Layer Height Using Ground-Based Lidar [PDF]

, 2021
Man‐Hae Kim, Huidong Yeo, Soo-Jin Park, Do-Hyeon Park, Ali Omar, Tomoaki Nishizawa, Atsushi Shimizu, Sang‐Woo Kim   +7 more
openalex   +1 more source

Ten Years of Boundary-Layer and Wind-Power Meteorology at Høvsøre, Denmark

Boundary-layer Meteorology, 2015
Operational since 2004, the National Centre for Wind Turbines at Høvsøre, Denmark has become a reference research site for wind-power meteorology. In this study, we review the site, its instrumentation, observations, and main research programs.
A. Peña, R. Floors, A. Sathe, S. Gryning, R. Wagner, M. Courtney, X. Larsén, A. Hahmann, C. Hasager   +8 more
semanticscholar   +1 more source