Results 91 to 100 of about 2,747,147 (255)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Outer layer turbulence intensities in smooth- and rough-wall boundary layers
, 2013 Clear differences in turbulence intensity profiles in smooth, transitional and fully rough zero-pressure-gradient boundary layers are demonstrated, using the diagnostic plot introduced by Alfredsson, Segalini & Örlü (Phys. Fluids, vol.
Alfredsson, Henrik +2 more
core +1 more source
Ramp‐Like PM 2.5 Accumulation Process and Z‐Less Similarity in the Stable Boundary Layer
Geophysical Research Letters, 2020 Similar ramp‐like structures exist in the time variations of surface PM 2.5 accumulation during the four different heavy haze pollution processes in Beijing, from 3 November 2017 to 15 January 2018.
Yu Shi, Fei Hu
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Transient growth in the flow past a three-dimensional smooth roughness element [PDF]
, 2013 This work provides a global optimization analysis, looking for perturbations inducing the largest energy growth at a finite time in a boundary-layer flow in the presence of smooth three-dimensional roughness elements.
DE TULLIO, Marco +4 more
core +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Numerical simulation of boundary-layer control using MEMS actuation [PDF]
MEMS actuators and their effect on boundary layers is investigated using numerical simulation. The thesis is specifically focussed on jet actuators and their application to the targeted control of turbulent boundary layers.
Lockerby, Duncan A.
core