Results 81 to 90 of about 2,747,147 (255)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Turbulent dispersion in cloud-topped boundary layers [PDF]

, 2009
Compared to dry boundary layers, dispersion in cloud-topped boundary layers has received less attention. In this LES based numerical study we investigate the dispersion of a passive tracer in the form of Lagrangian particles for four kinds of atmospheric
Vilà-Guerau de Arellano, J. (author), Heus, T., H. J. J. Jonker, J. Vilà-Guerau de Arellano, Heus, T. (author), Verzijlbergh, R.A. (author), Jonker, H.J.J., R. A. Verzijlbergh, Verzijlbergh, R.A., Jonker, H.J.J. (author), T. Heus, Vilà-Guerau de Arellano, J.   +11 more
core   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Measurements in an urban-type boundary layer. [PDF]

, 2008
Wind tunnel measurements of the boundary layer flow over a very rough surface comprising a staggered array of cubes are presented and discussed. Attention is concentrated on the near-wall region, including the canopy region below the tops of the ...
Ian P. Castro, Reynolds, Ryan T., Ryan T. Reynolds, Castro, Ian P.   +3 more
core   +1 more source

Evolution and meteorological causes of fine particulate explosive growth events in Beijing, China, from 2013 to 2017

Atmospheric and Oceanic Science Letters, 2020
Based on online observations of fine particulate matter (PM2.5) for five consecutive years from January 2013 to December 2017 in Beijing, combined with simultaneous measurement of gaseous precursors and meteorological parameters, the evolution and ...
Shuzhen SHI, Zirui LIU, Zhongjun XU, Shuanghong YANG, Jingda LIU, Yuesi WANG   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mesoscale variability in the summer Arctic boundary layer

, 2009
Observations from the summer Arctic Ocean Experiment 2001 (AOE-2001) are analysed with a focus on the interactions between mesoscale and boundary-layer dynamics.
Tjernström, Michael,, Mauritsen, Thorsten,   +1 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Antecedent soil moisture prior to freezing can affect quantity, composition and stability of soil dissolved organic matter during thaw

Scientific Reports, 2017
There are large amounts of dissolved organic matter (DOM) released into the soil during spring thaw, but its bioavailability and components are still unknown.
Haohao Wu, Xingkai Xu, Weiguo Cheng, Pingqing Fu, Fayun Li   +4 more
doaj   +1 more source