Results 71 to 80 of about 1,102,249 (248)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
The curved kinetic boundary layer of active matter [PDF]
, 2017 The finite reorient-time of swimmers leads to a finite run length $\ell$ and the kinetic accumulation boundary layer on the microscopic length scale $\delta$ on a non-penetrating wall.
Brady, John F., Yan, Wen
core +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Vertically resolved characteristics of air pollution during two severe winter haze episodes in urban Beijing, China [PDF]
Atmospheric Chemistry and Physics, 2018 We conducted the first real-time continuous vertical measurements of particle extinction (bext), gaseous NO2, and black carbon (BC) from ground level to 260 m during two severe winter haze episodes at an urban site in Beijing, China.
Q. Wang +20 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
EnergiesAccurate photovoltaic (PV) power forecasting is critical for the stable operation of power systems. Existing methods rely solely on historical data, which significantly decline in forecasting accuracy at 3–4 h ahead.
Jinman Zhang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Atmosphere, 2018 PM2.5 data from major cities in the southern North China Plain during 2013–2015 were comprehensively analyzed relative to variation features, meteorology effects, and regional transport contributions.
Lili Wang +9 more
doaj +1 more source
Analysis of axisymmetric boundary layers
, 2018 Axisymmetric boundary layers are studied using integral analysis of the governing equations for axial flow over a circular cylinder. The analysis includes the effect of pressure gradient and focuses on the effect of transverse curvature on boundary layer
Kumar, Praveen, Mahesh, Krishnan
core +1 more source