Results 71 to 80 of about 347,783 (331)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

An inverse problem for quantum trees with observations at interior vertices

Networks and Heterogeneous Media, 2021
In this paper we consider a non-standard dynamical inverse problem for the wave equation on a metric tree graph. We assume that positive masses may be attached to the internal vertices of the graph.
Sergei Avdonin, Julian Edward
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Grain-boundary topological superconductor

Communications Physics, 2023
AbstractMajorana zero modes (MZMs) are of central importance for modern condensed matter physics and quantum information due to their non-Abelian nature, which thereby offers the possibility of realizing topological quantum bits. We here show that a grain boundary (GB) defect can host a topological superconductor (SC), with a pair of cohabitating MZMs ...
Morten Amundsen, Vladimir Juričić
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Chiral Dirac superconductors: Second-order and boundary-obstructed topology

Physical Review Research, 2020
We analyze the topological properties of a chiral p+ip superconductor for a two-dimensional metal and semimetal with four Dirac points. Such a system has been proposed to realize second-order topological superconductivity and host corner Majorana modes ...
Apoorv Tiwari, Ammar Jahin, Yuxuan Wang
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Topological boundaries of representations and coideals

Advances in Mathematics
For a locally compact quantum group $\mathbb{G}$, a (left) coideal is a (left) $\mathbb{G}$-invariant von Neumann subalgebra of $L^\infty(\mathbb{G})$. We introduce and analyze various generalizations of amenability and coamenability to coideals of discrete and compact quantum groups.
Anderson-Sackaney, Benjamin, Khosravi, Fatemeh   +1 more
openaire   +3 more sources

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Slicing Bing doubles

, 2006
Bing doubling is an operation which produces a 2-component boundary link B(K) from a knot K. If K is slice, then B(K) is easily seen to be boundary slice. In this paper, we investigate whether the converse holds.
Bing, Cooper, David Cimasoni, Freedman, Kawauchi, Ko, Murasugi, Rudolph, Sheiham   +8 more
core   +2 more sources