Results 31 to 40 of about 1,741,144 (328)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

On a Third-Order Three-Point Boundary Value Problem

International Journal of Mathematics and Mathematical Sciences, 2012
We consider a third-order three-point boundary value problem. We introduce a generalized polynomial growth condition to obtain the existence of a nontrivial solution by using Leray-Schauder nonlinear alternative, then we give an example to illustrate our
A. Guezane-Lakoud, N. Hamidane, R. Khaldi   +2 more
doaj   +1 more source

Boundary Terms for Massless Fermionic Fields [PDF]

, 1995
Local supersymmetry leads to boundary conditions for fermionic fields in one-loop quantum cosmology involving the Euclidean normal to the boundary and a pair of independent spinor fields.
Esposito, Giampiero, Morales-Tecotl, Hugo A., Pollifrone, Giuseppe   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

On a nabla fractional boundary value problem with general boundary conditions

AIMS Mathematics, 2020
In this article, we consider a nabla fractional boundary value problem with general boundary conditions. Brackins & Peterson [5] gave an explicit expression for the corresponding Green’s function.
Jagan Mohan Jonnalagadda
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Viscoelastic Boundary Value Problems

Irish Mathematical Society Bulletin, 1986
Some problems with linear viscoelastic materials can be reduced to corresponding problems in elasticity, provided that the boundary regions satisfy certain conditions. The present note gives an alternative derivation of a method which can be used when the boundary regions vary in a quite complicated manner.
openaire   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Mixed algorithm for solving boundary value problem

Computer Assisted Methods in Engineering and Science, 2023
Symbolic computation has been applied to Runge-Kutta technique in order to solve two-point boundary value problem. The unknown initial values are considered as symbolic variables, therefore they will appear in a system of algebraic equations, after the ...
Béla Paláncz, György Popper
doaj  

Dirichlet boundary value problem for Duffing's equation

Electronic Journal of Qualitative Theory of Differential Equations, 2013
We use direct variational method in order to investigate the dependence on parameter for the solution for a Duffing type equation with Dirichlet boundary value conditions.
Piotr Kowalski
doaj   +1 more source