Results 51 to 60 of about 2,235,088 (306)

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

Molecular Oncology, Volume 19, Issue 4, Page 1092-1116, April 2025.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana, Paloma Navarro, Iván Hernández, Alejandra Ramos, Ana Montero‐Calle, Pablo Cabezas‐Sainz, Maria J Barrero, Diego Megías, Borja Vilaplana‐Martí, Carolina Epifano, Déborah Gómez‐Dominguez, Sara Monzón, Isabel Cuesta, Laura Sánchez, Rodrigo Barderas, Jesús García‐Donas, Alberto Martín, Ignacio Pérez de Castro   +17 more
wiley   +1 more source

Boundary Terms for Massless Fermionic Fields [PDF]

, 1995
Local supersymmetry leads to boundary conditions for fermionic fields in one-loop quantum cosmology involving the Euclidean normal to the boundary and a pair of independent spinor fields.
Esposito, Giampiero, Morales-Tecotl, Hugo A., Pollifrone, Giuseppe   +2 more
core   +1 more source

Light-Front Quantisation as an Initial-Boundary Value Problem

, 1993
In the light front quantisation scheme initial conditions are usually provided on a single lightlike hyperplane. This, however, is insufficient to yield a unique solution of the field equations.
C. Dietmaier, E. Werner, F.G. Friedlander, G. Domokos, G. McCartor, G.'t Hooft, H. Leutwyler, H.C. Pauli, I.M. Gelfand, I.S. Gradshteyn, J. Schwinger, J.D. Bjorken, J.M. Namys?owski, K. Sundermeyer, L. Banyai, L. Faddeev, N.N. Bogolubov, P. Jordan, P.A.M. Dirac, P.A.M. Dirac, P.M. Morse, R. Courant, R. Jackiw, R.A. Neville, R.J. Perry, S. Fubini, S. Schlieder, S. Schweber, S.J. Chang, S.J. Chang, T. Heinzl, T. Heinzl, T. Heinzl, T. Heinzl, T. Myint-U, T. Suzuki   +35 more
core   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

On Bernoulli boundary value problem

Le Matematiche, 2007
We give a constructive proof of the existence and uniqueness of the solution, under certain conditions, by Picard’s iteration. Moreover Newton’s iteration method is considered for the numerical computation of the solution.
Francesco A. Costabile, Annarosa Serpe
doaj  

Boundary value problems for hypergenic function vectors

Journal of Inequalities and Applications, 2018
This article mainly studies the boundary value problems for hypergenic function vectors in Clifford analysis. Firstly, some properties of hypergenic quasi-Cauchy type integrals are discussed. Then, by the Schauder fixed point theorem the existence of the
Guiling Zhang, Chong Li, Yonghong Xie
doaj   +1 more source

Measuring the capacity of yeast for surface display of cell wall‐anchored protein isoforms by using β‐lactamase as a reporter enzyme

FEBS Open Bio, Volume 15, Issue 4, Page 573-579, April 2025.
Yeast surface display (YSD) uses genetically modified yeast to immobilize recombinant enzymes on the cell surface. To quantify the efficiency of YSD, β‐lactamase was fused to selected cell wall proteins and enzyme activity was measured spectrophotometrically at 482 nm using nitrocefin as substrate. This system enables the monitoring of enzyme activity,
Tea Martinić Cezar, Antonia Paić, Stefani Prekpalaj, Renata Teparić, Bojan Žunar, Igor Stuparević   +5 more
wiley   +1 more source

Fractional order iterative boundary value problem

Boletim da Sociedade Paranaense de Matemática
In the present paper, we establish the existence and uniqueness solution for an iterative differential equation involving caputo fractional derivative of order ...
Manal Menchih, Khalid Hilal, M'hamed Elomari, Ahmed Kajouni   +3 more
doaj   +1 more source

Fractional boundary value problems [PDF]

Fractional Calculus and Applied Analysis, 2022
Abstract We study some functionals associated with a process driven by a fractional boundary value problem (FBVP for short). By FBVP we mean a Cauchy problem with boundary condition written in terms of a fractional equation, that is an equation involving time-fractional derivative in the sense of Caputo.
openaire   +2 more sources

Boundary value problems for the Helmholtz equation in a half-plane [PDF]

, 1994
The Dirichlet and impedance boundary value problems for the Helmholtz equation in a half-plane with bounded continuous boundary data are studied. For the Dirichlet problem the solution can be constructed explicitly. We point out that, for wavenumbers k >
Chandler-Wilde, SN
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