Results 51 to 60 of about 15,810,034 (284)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Modeling social conformity and peer pressure in opinion dynamics: the role of dynamic interaction structures

Frontiers in Physics
With the advent of modern media platforms, the dissemination of information has become faster and more far-reaching than ever before. These platforms amplify susceptibility to societal influences, as individuals respond to widely circulating information ...
Kanako Shibata, Isamu Okada
doaj   +1 more source

Spectral radius through time of the simulations that used the H-K bounded confidence model with different values of ϵ.

, 2022
Spectral radius through time of the simulations that used the H-K bounded confidence model with different values of ϵ.
Gentry White (756187), Johnathan A. Adams (13905657), Robyn P. Araujo (13905660)   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A Social Network Group Decision-Making Method for Flood Disaster Chains Considering Evolutionary Trends and Decision-Makers’ Risk Preferences

Mathematics
To address the impact of the dynamic evolution of flood disaster chains and decision-makers’ (DMs’) risk preference heterogeneity on group decision-making, this study proposes a social network group decision-making method that integrates the evolutionary
Ruohan Ma, Zhiying Wang, Lemei Zhu, Anbang Zhang, Yiwen Wang   +4 more
doaj   +1 more source

Confidence predicts speed-accuracy tradeoff for subsequent decisions

eLife, 2019
When external feedback about decision outcomes is lacking, agents need to adapt their decision policies based on an internal estimate of the correctness of their choices (i.e., decision confidence).
Kobe Desender, Annika Boldt, Tom Verguts, Tobias H Donner   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Min-max flow, k, through time of the simulations that used the H-K bounded confidence model with different values of ϵ.

, 2022
Min-max flow, k, through time of the simulations that used the H-K bounded confidence model with different values of ϵ.
Gentry White (756187), Johnathan A. Adams (13905657), Robyn P. Araujo (13905660)   +2 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Bounded confidence, radical groups, and charismatic leaders [PDF]

, 2014
By few simple extensions it is possible to model radical groups, charismatic leaders and processes of radicalization in the bounded confidence framework. In the resulting model we get a lot of surprising (non-)monotonicities.
Hegselmann, Rainer
core   +1 more source