Results 71 to 80 of about 15,810,034 (284)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
eLife, 2016 Many decisions are thought to arise via the accumulation of noisy evidence to a threshold or bound. In perception, the mechanism explains the effect of stimulus strength, characterized by signal-to-noise ratio, on decision speed, accuracy and confidence.
Ariel Zylberberg +2 more
doaj +1 more source
Probabilistic analysis of agent-based opinion formation models
Scientific Reports, 2023 When agent-based models are developed to capture opinion formation in large-scale populations, the opinion update equations often need to embed several complex psychological traits.
Carlos Andres Devia, Giulia Giordano
doaj +1 more source
Smoothed Bounded-Confidence Opinion Dynamics on the Complete Graph [PDF]
, 2022 We present and analyze a model for how opinions might spread throughout a network of people sharing information. Our model is called the smoothed bounded-confidence model and is inspired by the bounded-confidence model of opinion dynamics proposed by ...
Valore-Caplan, Solomon
core +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
The Combination of Pairwise and Group Interactions Promotes Consensus in Opinion Dynamics
Complexity, 2021 In complex systems, agents often interact with others in two distinct types of interactions, pairwise interaction and group interaction. The Deffuant–Weisbuch model adopting pairwise interaction and the Hegselmann–Krause model adopting group interaction ...
Xiaoxuan Liu +4 more
doaj +1 more source
Bounded confidence, radical groups, and charismatic leaders
, 2021 By few simple extensions it is possible to model radical groups, charismatic leaders and processes of radicalization in the bounded confidence framework. In the resulting model we get a lot of surprising (non-)monotonicities.
Hegselmann, Rainer
core
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Adaptive stochastic model predictive control of linear systems using Gaussian process regression
IET Control Theory & Applications, 2021 This paper presents a stochastic model predictive control method for linear time‐invariant systems subject to state‐dependent additive uncertainties modelled by Gaussian process (GP).
Fei Li, Huiping Li, Yuyao He
doaj +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source