Results 91 to 100 of about 45,775 (301)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Sign changing solutions of the Hardy–Sobolev–Maz'ya equation

open access: yesAdvances in Nonlinear Analysis, 2014
In this article we will study the existence, multiplicity and Morse index of sign changing solutions for the Hardy–Sobolev–Maz'ya (HSM) equation in bounded domain and involving critical growth.
Ganguly Debdip
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Cesàro Summable Sequence Spaces over the Non-Newtonian Complex Field

open access: yesJournal of Probability and Statistics, 2016
The spaces ω0p, ωp, and ω∞p can be considered the sets of all sequences that are strongly summable to zero, strongly summable, and bounded, by the Cesàro method of order 1 with index p.
Uğur Kadak
doaj   +1 more source

On existence of positive solutions of coupled integral boundary value problems for a nonlinear singular superlinear differential system

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2012
By constructing a special cone and using fixed point index theory, this paper investigates the existence of positive solutions of singular superlinear coupled integral boundary value problems for differential systems $$\left\{ \begin{array}{ll} -x''(t ...
Yujun Cui, Jingxian Sun
doaj   +1 more source

Functions of Exponential Type are Differences of Functions of Bounded Index

open access: yes, 1977
The notion of entire function of Bounded Index is by now well established. It may be stated as follows.An entire function f(z) is said to be of Bounded Index if for some fixed sfor all n and all z. (See [1], [2].)
Shantilal N. Shah
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

On the Ritt order of a certain class of functions

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1983
The authors introduce the notions of Ritt order and lower order to functions defined by the series ∑1∞fn(s)exp(−λns) where (λn) is a D-sequence and fn(s) are entire functions of bounded index.
R. Parvatham, J. Thangamani
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

QUALITATIVE AND QUANTITATIVE ESTIMATES FOR MINIMAL HYPERSURFACES WITH BOUNDED INDEX AND AREA [PDF]

open access: yes, 2016
We prove qualitative estimates on the total curvature of closed minimal hypersurfaces in closed Riemannian manifolds in terms of their index and area, restricting to the case where the hypersurface has dimension less than seven.
Buzano, Reto   +4 more
core   +1 more source

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