Results 131 to 140 of about 45,775 (301)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Degeneration of 7-dimensional minimal hypersurfaces which are stable or have bounded index
, 2022 A 7-dimensional area-minimizing embedded hypersurface $M$ will in general have a discrete singular set. The same is true if $M$ is stable, or has bounded index, provided $H^6(sing M) = 0$.
Edelen, Nick
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
On index of total boundedness of (strictly) o-bounded groups
, 2002 Let G be a metrizable topological group. Denote by itb(G) the smallest cardinality of a cover of G by totally bounded subsets of G. A group G is defined to be σ-bounded if itb(G)⩽ℵ0.
Taras Banakh, Banakh, Taras
core +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Bounded Disorder: The Effect of the Index
, 2007 In this paper we complete the analysis done by Ramakrishna and Mukhopadhyay for a data node in the Bounded Disorder (BD) file organization of Litwin and Lomet, by introducing the B-tree index into the model. Also, we extend the analysis to the case of BD
Ricardo A. Baeza-Yates
core
A new asymmetric bounded loss-based process capability index [PDF]
, 2010 Process capability indices such as Cp, Cpk, Cpu and Cpl are common metrics to evaluate and predict the performance of a process. Although higher process capability indices indicate higher process “quality”, but a high quality process does not necessarily
Ismail, Yusof +3 more
core
Entire Functions of Bounded L-Index: Its Zeros and Behavior of Partial Logarithmic Derivatives
, 2017 In this paper, we obtain new sufficient conditions of boundedness of L-index in joint variables for entire function in Cn functions. They give an estimate of maximum modulus of an entire function by its minimum modulus on a skeleton in a polydisc and ...
Oleh Skaskiv, Andriy Bandura
core +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source