Understanding and Teaching the Cold War. Ed. Matthew Masur. The Harvey Goldberg Series for Understanding and Teaching History. Madison: University of Wisconsin Press, 2017. xi, 354 pp. Notes. Bibliography. Index. Photographs. $34.95, hard bound. [PDF]
Richard Crockatt
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We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Beyond the Monastery Walls: The Ascetic Revolution in Russian Orthodox Thought, 1814–1914. By Patrick Lally Michelson. Madison, Wis.: University of Wisconsin Press, 2017. xi, 291 pp. Notes. Index. $69.95, hard bound. [PDF]
Stephen K. Batalden
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Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Quantitative Estimates on the Singular Set of Minimal Hypersurfaces with Bounded Index [PDF]
Nicolau S. Aiex +2 more
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Improving upper bounds for the distinguishing index
Summary: The distinguishing index of a graph \(G\), denoted by \(D^\prime(G)\), is the least number of colours in an edge colouring of \(G\) not preserved by any non-trivial automorphism. We characterize all connected graphs \(G\) with \(D^\prime(G)\geq \Delta(G)\).
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ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
New bounds for the acyclic chromatic index
An edge coloring of a graph $G$ is called an acyclic edge coloring if it is proper and every cycle in $G$ contains edges of at least three different colors. The least number of colors needed for an acyclic edge coloring of $G$ is called the acyclic chromatic index of $G$ and is denoted by $a'(G)$.
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SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
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