Results 51 to 60 of about 5,611 (266)
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Totally Bounded Sets of Precompact Linear Operators [PDF]
Proceedings of the American Mathematical Society, 1969 1. Introduction. In this paper several characterizations of totally bounded sets of precompact operators are given. These lead to an affirmative solution of the conjecture that a collectively compact set A is totally bounded iff Si*= {K*: KCSi} is collectively compact.
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Norm Properties of $S$-Universal Operators
Communications in Advanced Mathematical Sciences, 2020 We investigate the norm properties of a generalized derivation on a norm ideal $\mathcal{J}$ in $\mathcal{B}(H)$, the algebra of bounded linear operators on a Hilbert space $H$.
Joshua Muholo, Job Bonyo
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Stability for periodic evolution families of bounded linear operators [PDF]
Surveys in Mathematics and its Applications, 2015 The long time behavior for solutions of evolution periodic equations are reviewed.
Olivia Saierli
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Restrictions of bounded linear operators: Closed range [PDF]
Proceedings of the American Mathematical Society, 2006 Let \(X\) be a Banach space and \(W\) a linear subspace of \(X\) which is a continuously embedded Banach space. Let \(T\) be an operator on \(X\) such that \(W\) is \(T\)-invariant, and let \(T_W\) be the restriction of \(T\) to \(W\), which is continuous on \(W\) by the closed graph theorem.
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Bounded linear operators on finite dimensional probabilistic normed spaces [PDF]
Surveys in Mathematics and its Applications, 2013 Probabilistic normed spaces were introduced by Serstnev and have been redefined by Alsina, Schweizer, and Sklar. In this paper, we obtain some conditions under which linear operators on finite dimensional probabilistic normed spaces are bounded and ...
Mahmood Haji Shaabani +1 more
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