Results 61 to 70 of about 6,008 (260)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Norm Properties of $S$-Universal Operators

Communications in Advanced Mathematical Sciences, 2020
We investigate the norm properties of a generalized derivation on a norm ideal $\mathcal{J}$ in $\mathcal{B}(H)$, the algebra of bounded linear operators on a Hilbert space $H$.
Joshua Muholo, Job Bonyo
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Bounded linear operators on finite dimensional probabilistic normed spaces [PDF]

Surveys in Mathematics and its Applications, 2013
Probabilistic normed spaces were introduced by Serstnev and have been redefined by Alsina, Schweizer, and Sklar. In this paper, we obtain some conditions under which linear operators on finite dimensional probabilistic normed spaces are bounded and ...
Mahmood Haji Shaabani , Mohammad Baseri Nezhad   +1 more
doaj  

Orthogonality of bounded linear operators

Linear Algebra and its Applications, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Puja Ghosh, Debmalya Sain, Kallol Paul
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Upper Bounds for the Euclidean Operator Radius and Applications

Journal of Inequalities and Applications, 2009
The main aim of the present paper is to establish various sharp upper bounds for the Euclidean operator radius of an n-tuple of bounded linear operators on a Hilbert space.
doaj   +1 more source

Note on the Invariance Properties of Operator Products Involving Generalized Inverses

Abstract and Applied Analysis, 2014
We investigate further the invariance properties of the bounded linear operator product AC1 B1 D and its range with respect to the choice of the generalized inverses X and Y of bounded linear operators.
Xiaoji Liu, Miao Zhang, Yaoming Yu
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source