Results 51 to 60 of about 6,008 (260)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Modules and Bounded Linear Operators

Journal of Al-Nahrain University-Science, 2016
An associated R-module of T, which is denoted by V_(T,T^* ) is given, Where V is an inner product space and T is bounded linear operator on V. We study in this paper properties of T which effects V_(T,T^* ) and conversely.
Muna Jasim, Manal Ali
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

One Parameter Composite Semigroups of Linear Bounded Operators in Strong Operator Topology of Schatten Class Cp [PDF]

Engineering and Technology Journal, 2011
For semigroups of linear bounded operators on Hilbert spaces, the problem of being in Cp , 0 ...
Samir Kasim Hassan, Al-Taie M, Al-Malki Anam, Al-Attar Abeer, Mustafa Khaleel Ismael, Fatema Ahmed Sadeq, Radhi A .Zboon, Jehad R.Kider, Samir K .Hassan, Hussain J. M. Alalkawi, Raad H. Majid, Rawaa A. Alomairy, Luma Abdul Ghani Zghair, Hadia Kadhim J.Al-Ogili, Assifa M. Mohamad, Abbas Sheyaa Alwan, Haider L. Aneed, Assim H Yousif, Salema Sultan Salman, Abbas Hussien Miry, Abduladhem A.Ali, Mohammed Zeki Al-Faiz, Sabah N. mahmood, Khansaa Dawood Selman, Shaymaa Tareq Kadhim   +24 more
doaj   +1 more source

A Lower Bound for the Differences of Powers of Linear Operators [PDF]

Acta Mathematica Sinica, English Series, 2006
The authors prove that, if \(L\) is a quasi-nilpotent bounded linear operator in a Banach space \(X\) such that \(L \neq 0\), then \[ \liminf_{n\to\infty}(n+1)\|(I-L)^nL\|\geq {\frac{1}{e}}. \] They also prove that, for any \(T\in {\mathcal L}(X)\), either (i) \(\limsup_{n\to\infty}(n+1)\|(I-T)T^n\|\geq \frac{1}{e}\), or (ii) \(\limsup_{n\to\infty}(n+1)
Malinen Jarmo, Turunen Ville, Nevanlinna Olavi, Yuan Zhijian   +3 more
openaire   +2 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

On bounded linear functional operations [PDF]

Transactions of the American Mathematical Society, 1934
The set of all bounded linear functional operations on a given vector spacet plays an important role in the consideration of linear functional operations. For the sake of greater definiteness it is desirable to know the form of such operations and a space determined thereby.
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Stability for periodic evolution families of bounded linear operators [PDF]

Surveys in Mathematics and its Applications, 2015
The long time behavior for solutions of evolution periodic equations are reviewed.
Olivia Saierli
doaj  

Extension of Bounded Linear Operators

Journal of Advanced College of Engineering and Management, 2016
<p>In this article the problem entitled when does every member of a class of operators T : E → Y admit an extension operator T : X → Y in different approaches like injective spaces, separable injective spaces, the class of compact operators and extension  Into C(K ) spaces has-been studied.</p><p><strong>Journal of Advanced ...
Prakash Muni Bajryacharya, Keshab Raj Phulara   +1 more
openaire   +2 more sources