Results 51 to 60 of about 2,270,323 (368)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
(WP 2014-03) Bounded Rationality and Bounded Individuality [PDF]
, 2014 This paper argues that since the utility function conception of the individual is derived from standard rationality theory, the view that rationality is bounded suggests that individuality should also be seen as bounded.
Davis, John B.
core +1 more source
Learning and Visceral Temptation in Dynamic Saving Experiments [PDF]
, 2009 This paper tests two explanations for apparent undersaving in life cycle models: bounded rationality and a preference for immediacy. Each was addressed in a separate experimental study.
Brown, Alexander L. +2 more
core +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Medicine as a Science of Design
Azafea: Revista de Filosofía, 2022 There is a long dispute in the philosophy of medicine between those who consider medicine as an applied science and those who defend that is an art. We defend an alternative: medicine is a science of design. Doing this allows us to introduce prescriptive
Ana Cuevas Badallo +1 more
doaj +1 more source
Law for the Common Man: An Individual-Level Theory of Values, Expanded Rationality, and the Law [PDF]
, 2011 This article makes an admittedly bold attempt at outlining an analytical framework for addressing this question. Instead of looking at the legal implications of bounded rationality -- an exercise highly worthy in its own right -- this article advances a ...
Licht, Amir N.
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Two-Sided Matching with Bounded Rationality: A Stochastic Framework for Personnel Selection
MathematicsPersonnel selection represents a two-sided matching problem in which firms compete for qualified candidates by designing job-offer packages. While traditional models assume fully rational agents, real-world decision-makers often face bounded rationality ...
Saeed Najafi-Zangeneh +2 more
doaj +1 more source
The bounded rationality of the educational choices
Encyclopaideia, 2015 Nowadays, models adopted by the educational systems met with rigidities and doctrinal axioms that are limiting the efficacy of the interventions. This is due to a reduced capacity of adaptability to the reality.
Simone Digennaro, Antonio Borgogni
doaj +1 more source