Results 71 to 80 of about 477,215 (294)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

A Survey on Entropy and Economic Behaviour

Entropy, 2020
Entropy plays a significant role in the study of games and economic behaviour in several ways. A decision maker faced with an n-fold repetition of a decision-making problem needs to apply strategies that become increasingly complex as n increases.
Ziv Hellman, Ron Peretz
doaj   +1 more source

Economics and psychology.Perfect rationality versus bounded rationality [PDF]

Classical mathematical algorithms often fail to identify in time when the international financial crises occur although, as the classical theory of choice would suggest, the economic agents are rational and the markets are or should be efficient and ...
Schilirò, Daniele
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Why bounded rationality (in epistemology)? [PDF]

Bounded rationality gets a bad rap in epistemology. It is argued that theories of bounded rationality are overly context‐sensitive; conventionalist; or dependent on ordinary language (Carr, 2022; Pasnau, 2013). In this paper, I have three aims. The first
Thorstad, David
core   +3 more sources

Optimization Decisions with Bounded Rationality in Customer-Intensive Services Under Gumbel Distributions

Axioms
Customers’ bounded rationality significantly influences the effectiveness of advertising and related decision-making in customer-intensive services. This paper, based on the M/M/1 queuing model and incorporating the characteristics of customers’ bounded ...
Gang Fu, Minghui Jiang, Wentao Zhan
doaj   +1 more source

Agriculture and natural resources business owners economic and communication concerns early in the COVID-19 pandemic

Advancements in Agricultural Development, 2020
The purpose of this study was to describe agriculture and natural resource (ANR) leader business owners’ initial concerns and feelings about the impacts of the 2019 novel coronavirus (COVID-19) pandemic.
Lauri Baker, Michaela Kandzer, Shelli Rampold, Christy Chiarelli, Hikaru Peterson, Ashley McLeod-Morin   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Structural stability and robustness to bounded rationality [PDF]

The introduction of a small amount of bounded rationality into a model sometimes has little effect, and sometimes has a dramatic impact on predicted behavior.
Canning, David, Anderlini, Luca
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source