Results 51 to 60 of about 15,568 (347)
The bounded rationality of the educational choices
Encyclopaideia, 2015 Nowadays, models adopted by the educational systems met with rigidities and doctrinal axioms that are limiting the efficacy of the interventions. This is due to a reduced capacity of adaptability to the reality.
Simone Digennaro, Antonio Borgogni
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Medicine as a Science of Design
Azafea: Revista de Filosofía, 2022 There is a long dispute in the philosophy of medicine between those who consider medicine as an applied science and those who defend that is an art. We defend an alternative: medicine is a science of design. Doing this allows us to introduce prescriptive
Ana Cuevas Badallo +1 more
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
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Two-Sided Matching with Bounded Rationality: A Stochastic Framework for Personnel Selection
MathematicsPersonnel selection represents a two-sided matching problem in which firms compete for qualified candidates by designing job-offer packages. While traditional models assume fully rational agents, real-world decision-makers often face bounded rationality ...
Saeed Najafi-Zangeneh +2 more
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FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
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Adaptive Rationality, Adaptive Behavior and Institutions [PDF]
Журнал институциональных исследований, 2015 The economic literature focused on understanding decision-making and choice processes reveals a vast collection of approaches to human rationality. Theorists’ attention has moved from absolutely rational, utility-maximizing individuals to boundedly ...
Volchik Vyacheslav, V. +2 more
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
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Studies in Business and Economics, 2020 More than 100 years ago, Herbert A. Simon wrote the book “The sciences of the artificial” (1916) where he presented Economics as an artificial science. Even though back then the mainstream economics promoted the idea of , Simon’s perspective of man was ...
Camelia Ghiurca
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