Results 81 to 90 of about 398,756 (302)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

The Simonian bounded rationality hypothesis and the expectation formation mechanism [PDF]

open access: yes
. In the 1980s and at beginning of the 1990s the debate on expectation formation mechanism was dominated by the rational expectation hypothesis. Later on, more interest was directed towards alternative approaches to expectations analysis, mainly based on
Kowalski, Tadeusz
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Testing Bounded Rationality Against Full Rationality in Job Changing Behavior [PDF]

open access: yes
In this paper I question the hypothesis of full rationality in the context of job changing behaviour, via simple econometric explorations on microdata drawn from WHIP (Worker Histories Italian Panel).
Bruno Contini
core  

Parametric management of economic actor behaviour under bounded rationality

open access: yesСтратегические решения и риск-менеджмент, 2017
The article explores parametric management of economic entity production volume within framework of weak and strong hypothesis of bounded rationality. The concept of parametric management with the example of economic entity behavior modeling under the ...
A. YU. Obydenov
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Extending the Bounded Rationality Model: The Distributed Cognition Approach [PDF]

open access: yes
The way Simon, and the major part of the scholars, presented and used bounded rationality directly refers to human computational capabilities (or “brute-force”).
Secchi Davide, Bardone Emanuele
core  

Bounded Epistemic Rationality and Norms of Inquiry

open access: yesArs & Humanitas
Epistemology has recently taken a zetetic turn: a shift in emphasis from the study of norms of belief to norms of inquiry. In this paper, I argue that a non-ideal approach to zetetic normativity can provide norms of inquiry for bounded, psychologically ...
Nastja Tomat
doaj   +1 more source

SOME PSYCHOLOGICAL CAUSES OF THE FINANCIAL CRISIS [PDF]

open access: yesCES Working Papers, 2015
Besides the numerous effects that the financial crisis of 2007 has produced over the entire global economy, its onset has reopened fundamental discussions on the methodology of the economic science.
Paula-Elena DIACON
doaj  

The recognition heuristic: A decade of research

open access: yesJudgment and Decision Making, 2011
The recognition heuristic exploits the basic psychological capacity for recognition in order to make inferences about unknown quantities in the world.
Gerd Gigerenzer   +4 more
doaj   +1 more source

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