Results 91 to 100 of about 12,317 (302)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Extending the Bounded Rationality Model: The Distributed Cognition Approach [PDF]

The way Simon, and the major part of the scholars, presented and used bounded rationality directly refers to human computational capabilities (or “brute-force”).
Secchi Davide, Bardone Emanuele
core  

SOME PSYCHOLOGICAL CAUSES OF THE FINANCIAL CRISIS [PDF]

CES Working Papers, 2015
Besides the numerous effects that the financial crisis of 2007 has produced over the entire global economy, its onset has reopened fundamental discussions on the methodology of the economic science.
Paula-Elena DIACON
doaj  

The recognition heuristic: A decade of research

Judgment and Decision Making, 2011
The recognition heuristic exploits the basic psychological capacity for recognition in order to make inferences about unknown quantities in the world.
Gerd Gigerenzer, Daniel G. Goldstein, Julian N. Marewski, Rüdiger F. Pohl, Oliver Vitouch   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The Problem With Bounded Rationality On Behavioral Assumptions in the Theory of the Firm [PDF]

I discuss and compare alternative approaches to integrating bounded rationality with the theory of economic organization, concentrating on the organizational capabilities approach, which is strongly influenced by the works of Nelson and Winter ...
Nicolai J. Foss
core  

Bounded Epistemic Rationality and Norms of Inquiry

Ars & Humanitas
Epistemology has recently taken a zetetic turn: a shift in emphasis from the study of norms of belief to norms of inquiry. In this paper, I argue that a non-ideal approach to zetetic normativity can provide norms of inquiry for bounded, psychologically ...
Nastja Tomat
doaj   +1 more source

Bounded rationality, enactive problem solving, and the neuroscience of social interaction. [PDF]

Front Psychol, 2023
Viale R, Gallagher S, Gallese V.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Regions of rationality: Maps for bounded agents [PDF]

An important problem in descriptive and prescriptive research in decision making is to identify “regions of rationality,” i.e., the areas for which heuristics are and are not effective.
Robin Hogarth, Natalia Karelaia
core