Results 51 to 60 of about 3,723,489 (302)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Bounds on the disparity and separation of tournament solutions

Discrete Applied Mathematics, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Felix Brandt 0001, Andre Dau, Hans Georg Seedig   +2 more
openaire   +3 more sources

Two-species competition models with fitness-dependent dispersalon non-convex bounded domains

Electronic Journal of Differential Equations, 2015
In this article, we show the existence of global bounded solutions to a two-species competition models with fitness-dependent dispersal posed in a bounded domain $\Omega\subset\mathbb{R}^N$ with smooth boundary. In particular, we remove the convexity
Xie Li
doaj  

On the Method of Guiding Functions in the Problem of the Existence of Bounded Solutions for Differential Inclusions

Известия Иркутского государственного университета: Серия "Математика"
At the end of the 20th — beginning of the 21st centuries, in connection with the new opportunity of applications to current problems of mathematics, mechanics, control theory, physics and other sciences, the need arose for a significant expansion of the ...
S. V. Kornev, P. S. Korneva, V.V. Obukhovskii   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A unified framework for resource-bounded autonomous agents interacting with unknown environments [PDF]

, 2011
The aim of this thesis is to present a mathematical framework for conceptualizing and constructing adaptive autonomous systems under resource constraints.

core   +2 more sources

Boundedness of solutions to fourth order differential equations with oscillatory restoring and forcing terms

Electronic Journal of Differential Equations, 2006
This article concerns the fourth order differential equation $$ x^{(iv)}+ax'''+bx''+g(x')+h(x)=p(t). $$ Using the Cauchy formula for the particular solution of non-homogeneous linear differential equations with constant coefficients, we prove that ...
Babatunde S. Ogundare
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source