Results 101 to 110 of about 5,782,798 (335)
A Novel Variational Lower Bound for Inverse Reinforcement Learning [PDF]
, 2023 Yikang Gui, Prashant Doshi
openalex +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Estimates of Lp Modulus of Continuity of Generalized Bounded Variation Classes
Journal of Function Spaces, 2014 Some sharp estimates of the Lp1 ...
Heping Wang, Zhaoyang Wu
doaj +1 more source
New Generalized Inequalities for Functions of Bounded Variation
Cumhuriyet Science Journal, 2018 In this paper, firstly we obtain some generalized trapezoid and midpointtype inequalities for functions of bounded variation using two new generalized identitiesfor Riemann-Stieltjes integrals. Then quadrature formula is also provided.
Mehmet Zeki Sarıkaya, Hüseyin Budak
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Selections of bounded variation for roots of smooth polynomials [PDF]
, 2020 Adam Parusiński, Armin Rainer
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
A Generalization Bound for Online Variational Inference [PDF]
, 2019 Badr-Eddine Chérief-Abdellatif +2 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source