Results 101 to 110 of about 17,219 (295)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
The Boundedness of Marcinkiewicz Integral Associated with Schrödinger Operator and Its Commutator
Journal of Function Spaces, 2014 The authors prove that Marcinkiewicz integral operator is not only are bounded on Lp, for ...
Dongxiang Chen, Dan Zou
doaj +1 more source
On the boundedness of solutions of difference-differential equations [PDF]
, 1960 Shohei Sugiyama
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Product metrics and boundedness
Applied General Topology, 2008 [EN] This paper looks at some possible ways of equipping a countable product of unbounded metric spaces with a metric that acknowledges the boundedness characteristics of the factors.
openaire +4 more sources
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Boundedness of solutions to nonlinear equations in Hilbert space [PDF]
, 1969 Athanassios G. Kartsatos
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A topological notion of boundedness
Manuscripta Mathematica, 1973 A topological boundedness notion is studied, which is proved to be productive. Classical theorems on compactness of Tychonoff, Alexander and Obreanu are generalized. A boundedness operator is defined and studied. Finally, a classification of all topological spaces is obtained according to boundedness criteria.
openaire +3 more sources
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
On the boundedness of an iterative procedure for solving a system of linear inequalities [PDF]
, 1970 H. D. Block, Simon A. Levin
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Boundedness in certain topological linear spaces [PDF]
, 1969 Bruce Barnes, Anup Kumar Roy
openalex +1 more source