Results 101 to 110 of about 142,415 (276)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Stability and boundedness of solutions of the initial value problem for a class of time-fractional diffusion equations

Advances in Difference Equations, 2017
The aim of this paper is to study the stability and boundedness of solutions of the initial value problem for a class of time-fractional diffusion equations.
Yanhua Wen, Xian-Feng Zhou, Jun Wang
doaj   +1 more source

An example concerning uniform boundedness of spectral measures [PDF]

, 1954
Shizuo Kakutani
openalex   +1 more source

On Rado's Boundedness Conjecture

Journal of Combinatorial Theory, Series A, 2006
AbstractWe prove that Rado's Boundedness Conjecture from Richard Rado's 1933 famous dissertation Studien zur Kombinatorik is true if it is true for homogeneous equations. We then prove the first nontrivial case of Rado's Boundedness Conjecture: if a1, a2, and a3 are integers, and if for every 24-coloring of the positive integers (or even the nonzero ...
Daniel J. Kleitman, Jacob Fox
openaire   +2 more sources

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Mathematical study of polycystic ovarian syndrome disease including medication treatment mechanism for infertility in women

AIMS Public Health
Among women of reproductive age, PCOS (polycystic ovarian syndrome) is one of the most prevalent endocrine illnesses. In addition to decreasing female fertility, this condition raises the risk of cardiovascular disease, diabetes, dyslipidemia, obesity ...
Maryam Batool, Muhammad Farman, Aqeel Ahmad, Kottakkaran Sooppy Nisar   +3 more
doaj   +1 more source

Weighted composition operators acting from the Lipschitz space to the space of bounded functions on a tree

, 2019
We study the weighted composition operators between the Lipschitz space and the space of bounded functions on the set of vertices of an infinite tree.
Hosokawa, Takuya
core  

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Global behavior of a discrete population model

AIMS Mathematics
In this work, the global behavior of a discrete population model $ \begin{equation*} \begin{cases} x_{n+1}& = \alpha x_n e^{-y_n}+\beta,\\ y_{n+1}& = \alpha x_n(1-e^{-y_n}), \end{cases}\quad n = 0,1,2,\dots, \end{equation*} $ is considered,
Linxia Hu, Yonghong Shen, Xiumei Jia
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source