Results 131 to 140 of about 187,605 (363)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
, 2012 In this paper we define square functions (also called Littlewood-Paley-Stein functions) associated with heat semigroups for Schr\"odinger and Laguerre operators acting on functions which take values in UMD Banach spaces.
Betancor, J. J. +3 more
core
On the existence and boundedness of square function operators on Campanato spaces [PDF]
, 2004 Yongzhong Sun
openalex +1 more source
, 2010 This paper is withdrawn because the results in the paper are included in a paper to be published in Mathematical and Computer ...
openaire +2 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
A Boundedness Trichotomy for the Stochastic Heat Equation [PDF]
, 2015 Le Chen, Davar Khoshnevisan, Kunwoo Kim
openalex +1 more source
Amalgams and \(\chi\)-boundedness
Journal of Graph Theory, 2017 Summary: A class of graphs is hereditary if it is closed under isomorphism and induced subgraphs. A class \(\mathcal G\) of graphs is \(\chi\)-bounded if there exists a function \(f:\mathbb{N} \to \mathbb{N}\) such that for all graphs \(G\in \mathcal{G}\), and all induced subgraphs \(H\) of \(G\), we have that \(\chi(H)\leq f(\omega(H))\).
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source