Results 61 to 70 of about 7,445 (247)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Boundedness and exponential stability of solutions to dynamic equations on time scales

Electronic Journal of Differential Equations, 2007
Making use of the generalized time scales exponential function, we give a new definition for the exponential stability of solutions for dynamic equations on time scales. Employing Lyapunov-type functions on time scales, we investigate the boundedness and
Ai-Lian Liu
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Verification of Computing Grids with Special Edge Conditions by Infinite Petri Nets

Моделирование и анализ информационных систем, 2015
A technique of the computing grid verification using invariants of infinite Petri nets was presented. Models of square grid structures in the form of parametric Petri nets for such edge conditions as connection of edges and truncated devices were ...
D. A. Zaitsev
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Fractional differentiation composition operators from Sp spaces to Hq spaces [PDF]

Mathematica Moravica
Let Sp be the space of functions analytic on the unit disk and whose derivatives belong to the Hardy space. In this article, we investigate the boundedness and compactness of the fractional differentiation composition operators from Sp spaces into Hardy ...
Borgohain Deepjyoti
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

On behaviours of functional Volterra integro-differential equations with multiple time lags

Journal of Taibah University for Science, 2018
In this paper, the authors consider a non-linear Volterra integro-differential equation (NVIDE) of first order with multiple constant time lags. They obtain new sufficient conditions on stability (S), boundedness (B), global asymptotic stability (GAS) of
Cemil Tunç, Osman Tunç
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Semantic types of bound and aspectual conditions of their realization

Opera slavica, 2015
The article considers the various semantic types of verbal action bound. Based on identified aspectual structures of holistic artistic texts, and analyzing the aspectual conditions for implementing these types of bound, it can be concluded that, there ...
Ljudmila Valova
doaj