Results 81 to 90 of about 142,415 (276)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Multilinear analysis for discrete and periodic pseudo-differential operators in Lp-spaces

open access: yesRevista Integración, 2018
In this note we announce our investigation on the Lp properties for periodic and discrete multilinear pseudo-differential operators. First, we review the periodic analysis of multilinear pseudo-differential operators by showing classical multilinear ...
Duván Cardona, Vishvesh Kumar
doaj  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

A note on the existence of Psi-bounded solutions for a system of differential equations on R

open access: yesElectronic Journal of Differential Equations, 2008
We prove a necessary and sufficient condition for the existence of Psi-bounded solutions of a linear nonhomogeneous system of ordinary differential equations on R.
Aurel Diamandescu
doaj  

ON SPECTRAL BOUNDEDNESS [PDF]

open access: yesJournal of the Korean Mathematical Society, 2003
For linear operators between Banach algebras "spectral boundedness" is derived from ordinary boundedness by substituting spectral radius for norm. The interplay between this concept and some of its near relatives is conspicuous in a result of Curto and Mathieu. It is familiar that a linear operator T : X !
openaire   +2 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Decision Problems for Petri Nets with Names

open access: yes, 2010
We prove several decidability and undecidability results for nu-PN, an extension of P/T nets with pure name creation and name management. We give a simple proof of undecidability of reachability, by reducing reachability in nets with inhibitor arcs to it.
de Frutos-Escrig, David   +1 more
core  

Product metrics and boundedness

open access: yesApplied General Topology, 2008
[EN] This paper looks at some possible ways of equipping a countable product of unbounded metric spaces with a metric that acknowledges the boundedness characteristics of the factors.
openaire   +4 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

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