Results 81 to 90 of about 7,445 (247)

Continuability and boundedness of solutions to nonlinear second-order differential equations

Electronic Journal of Differential Equations, 2010
Continuability, boundedness, and monotonicity of solutions for a class of second-order nonlinear differential equations are discussed. It is proved that all solutions are eventually monotonic and can be extended to infinity under some natural ...
Lianwen Wang, Rhonda McKee, Larysa Usyk
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

On Boundedness

, 2010
This paper is withdrawn because the results in the paper are included in a paper to be published in Mathematical and Computer ...
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A note on the qualitative analysis of Volterra integro-differential equations

Journal of Taibah University for Science, 2019
The aim of paper is to analyse some qualitative properties of solutions of nonlinear Volterra integro-differential equations (VIDDEs) with constant delay and Volterra integro-differential equations (VIDEs) without delay by means of the Razumikhin method.
Cemil Tunç, Osman Tunç
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Stability for trajectories of periodic evolution families in Hilbert spaces

Electronic Journal of Differential Equations, 2014
Let $q$ be a positive real number and let $A(\cdot)$ be a $q$-periodic linear operator valued function on a complex Hilbert space $H$, and let $D$ be a dense linear subspace of $H$.
Dorel Barbu, Joel Blot, Constantin Buse, Olivia Saierli   +3 more
doaj  

Amalgams and \(\chi\)-boundedness

Journal of Graph Theory, 2017
Summary: A class of graphs is hereditary if it is closed under isomorphism and induced subgraphs. A class \(\mathcal G\) of graphs is \(\chi\)-bounded if there exists a function \(f:\mathbb{N} \to \mathbb{N}\) such that for all graphs \(G\in \mathcal{G}\), and all induced subgraphs \(H\) of \(G\), we have that \(\chi(H)\leq f(\omega(H))\).
openaire   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source