Results 121 to 130 of about 1,414,908 (321)
History-Bound Reelections [PDF]
SSRN Electronic Journal, 2015 We introduce history-bound reelections. In their simple form, they consist in a “ score-replication rule.” Under such a rule, an incumbent has to match the highest vote share he or she has obtained in any previous election in order to be reelected. We develop a simple three-period model to examine score-replication rules.
openaire +3 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
eco: R Package for Ecological Inference in 2x2 Tables
Journal of Statistical Software, 2011 eco is a publicly available R package that implements the Bayesian and likelihood methods proposed in Imai, Lu, and Strauss (2008b) for ecological inference in 2 X 2 tables as well as the method of bounds introduced by (Duncan and Davis 1953).
Kosuke Imai, Ying Lu, Aaron Strauss
doaj
Modes, bounds, and synthesis of optimal electromagnetic scatterers
New Journal of PhysicsThis paper presents an optimal synthesis of material distributions in obstacles for maximal extinction, scattering, or absorption. The material synthesis is based on an explicit construction utilizing the current distribution derived from physical bounds
Mats Gustafsson
doaj +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
On bounded functions with bounded 𝑛th differences [PDF]
Proceedings of the American Mathematical Society, 1959 We consider real valued functions f defined in a closed interval I (bounded or unbounded), with nth differences $$ \Delta _{h}^{n}f(x) = \sum\limits_{i} {{{{( - 1)}}^{{n - i}}}} \left( {\begin{array}{*{20}{c}} n \\ i \\ \end{array} } \right)f(x + ih) $$ bounded for some fixed n.
openaire +2 more sources
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source