Molnupiravir inhibits Bourbon virus infection and disease-associated pathology in mice [PDF]
Journal of VirologyBourbon virus (BRBV) is an emerging tick-borne virus that can cause severe and fatal disease in humans. BRBV is vectored via the Amblyomma americanum tick, which is widely distributed throughout the central, eastern, and southern United States ...
Gayan Bamunuarachchi +6 more
doaj +6 more sources
Bourbon Virus in Field-Collected Ticks, Missouri, USA [PDF]
Emerging Infectious Diseases, 2017 Bourbon virus (BRBV) was first isolated in 2014 from a resident of Bourbon County, Kansas, USA, who died of the infection. In 2015, an ill Payne County, Oklahoma, resident tested positive for antibodies to BRBV, before fully recovering.
Harry M. Savage +6 more
doaj +6 more sources
Essential Role of Interferon Response in Containing Human Pathogenic Bourbon Virus [PDF]
Emerging Infectious Diseases, 2019 Bourbon virus (BRBV) is a recently discovered tick-transmitted viral pathogen that is prevalent in the Midwest and southern United States. Since 2014, zoonotic BRBV infections have been verified in several human cases of severe febrile illness ...
Jonas Fuchs +3 more
doaj +7 more sources
Establishment of a Replicon Reporter of the Emerging Tick-Borne Bourbon Virus and Use It for Evaluation of Antivirals [PDF]
Frontiers in Microbiology, 2020 Bourbon virus (BRBV) was first isolated from a patient hospitalized at the University of Kansas Hospital in 2014. Since then, several deaths have been reported to be caused by BRBV infection in the Midwest and Southern United States. BRBV is a tick-borne
Siyuan Hao +7 more
doaj +6 more sources
Reverse Vaccinology Integrated with Biophysics Techniques for Designing a Peptide-Based Subunit Vaccine for Bourbon Virus [PDF]
BioengineeringDespite the seriousness of the disease carried by ticks, little is known about the Bourbon virus. Only three US states have recorded human cases of Bourbon virus (BRBV) infection; in all cases, a tick bite was connected with the onset of the illness. The
Taghreed N. Almanaa
doaj +6 more sources
ANP32 proteins from ticks and vertebrates are key host factors for replication of Bourbon virus across species [PDF]
Journal of VirologyBourbon virus (BRBV) is a tick-borne virus in the genus Thogotovirus in the Orthomyxoviridae family. BRBV was initially identified as the presumptive causative agent of a fatal human infection in 2014 and has since been identified in ticks in the Midwest,
Zhenyu Zhang +4 more
doaj +5 more sources
Prevalence of Bourbon and Heartland viruses in field collected ticks at an environmental field station in St. Louis County, Missouri, USA [PDF]
Ticks and Tick-Borne Diseases, 2023 Heartland and Bourbon viruses are pathogenic tick-borne viruses putatively transmitted by Amblyomma americanum, an abundant tick species in Missouri. To assess the prevalence of these viruses in ticks, we collected 2778 ticks from eight sampling sites at
Ishmael D. Aziati +9 more
doaj +4 more sources
Widespread Circulation of Tick-Borne Viruses in Virginia—Evidence of Exposure to Heartland, Bourbon, and Powassan Viruses in Wildlife and Livestock [PDF]
MicroorganismsEmerging tick-borne viruses such as Powassan virus (POWV), Bourbon virus (BRBV), and Heartland virus (HRTV), whilst rare, can cause severe health problems in humans.
Ahmed Garba +3 more
doaj +4 more sources
Experimental Infection of Amblyomma americanum (Acari: Ixodidae) With Bourbon Virus (Orthomyxoviridae: Thogotovirus). [PDF]
J Med Entomol, 2021 Abstract Following the recent discovery of Bourbon virus (BRBV) as a human pathogen, and the isolation of the virus from Amblyomma americanum (L.) collected near the location of a fatal human case, we undertook a series of experiments to assess the laboratory vector competence of this tick species for BRBV.
Godsey MS +6 more
europepmc +5 more sources
A panel of real-time PCR assays for the detection of Bourbon virus, Heartland virus, West Nile virus, and Trypanosoma cruzi in major disease-transmitting vectors. [PDF]
J Vet Diagn Invest, 2021 Vector-borne pathogens, such as Bourbon virus (BRBV), Heartland virus (HRTV), West Nile virus (WNV), and Trypanosoma cruzi (TCZ) are a great threat to public health and animal health. We developed a panel of TaqMan real-time PCR assays for pathogen surveillance. PCR targets were selected based on nucleic acid sequences deposited in GenBank.
Warang A, Zhang M, Zhang S, Shen Z.
europepmc +5 more sources