Results 11 to 20 of about 1,701,072 (179)

Therapeutic efficacy of favipiravir against Bourbon virus in mice. [PDF]

PLoS Pathogens, 2019
Bourbon virus (BRBV) is an emerging tick-borne RNA virus in the orthomyxoviridae family that was discovered in 2014. Although fatal human cases of BRBV have been described, little is known about its pathogenesis, and no antiviral therapies or vaccines ...
Traci L Bricker, Md Shafiuddin, Anshu P Gounder, Andrew B Janowski, Guoyan Zhao, Graham D Williams, Brett W Jagger, Michael S Diamond, Thomas Bailey, Jennie H Kwon, David Wang, Adrianus C M Boon   +11 more
doaj   +11 more sources

Essential Role of Interferon Response in Containing Human Pathogenic Bourbon Virus [PDF]

Emerging Infectious Diseases, 2019
Bourbon virus (BRBV) is a recently discovered tick-transmitted viral pathogen that is prevalent in the Midwest and southern United States. Since 2014, zoonotic BRBV infections have been verified in several human cases of severe febrile illness ...
Jonas Fuchs, Tobias Straub, Maximilian Seidl, Georg Kochs   +3 more
doaj   +8 more sources

ANP32 proteins from ticks and vertebrates are key host factors for replication of Bourbon virus across species [PDF]

Journal of Virology
Bourbon virus (BRBV) is a tick-borne virus in the genus Thogotovirus in the Orthomyxoviridae family. BRBV was initially identified as the presumptive causative agent of a fatal human infection in 2014 and has since been identified in ticks in the Midwest,
Zhenyu Zhang, Ishmael D. Aziati, Thomas Nipper, Adrianus C. M. Boon, Andrew Mehle   +4 more
doaj   +6 more sources

Reverse Vaccinology Integrated with Biophysics Techniques for Designing a Peptide-Based Subunit Vaccine for Bourbon Virus [PDF]

Bioengineering
Despite the seriousness of the disease carried by ticks, little is known about the Bourbon virus. Only three US states have recorded human cases of Bourbon virus (BRBV) infection; in all cases, a tick bite was connected with the onset of the illness. The
Taghreed N. Almanaa
doaj   +7 more sources

Establishment of a Replicon Reporter of the Emerging Tick-Borne Bourbon Virus and Use It for Evaluation of Antivirals [PDF]

Frontiers in Microbiology, 2020
Bourbon virus (BRBV) was first isolated from a patient hospitalized at the University of Kansas Hospital in 2014. Since then, several deaths have been reported to be caused by BRBV infection in the Midwest and Southern United States. BRBV is a tick-borne
Siyuan Hao, Kang Ning, Xiaomei Wang, Jianke Wang, Fang Cheng, Safder S. Ganaie, John E. Tavis, Jianming Qiu   +7 more
doaj   +7 more sources

Experimental Infection of Amblyomma americanum (Acari: Ixodidae) With Bourbon Virus (Orthomyxoviridae: Thogotovirus). [PDF]

J Med Entomol, 2021
Following the recent discovery of Bourbon virus (BRBV) as a human pathogen, and the isolation of the virus from Amblyomma americanum (L.) collected near the location of a fatal human case, we undertook a series of experiments to assess the laboratory ...
Godsey MS, Rose D, Burkhalter KL, Breuner N, Bosco-Lauth AM, Kosoy OI, Savage HM.   +6 more
europepmc   +6 more sources

Molecular, serological and in vitro culture-based characterization of Bourbon virus, a newly described human pathogen of the genus Thogotovirus. [PDF]

J Clin Virol, 2015
In June of 2014, a previously healthy man from Kansas with a recent history of tick exposure died from complications related to an illness marked by fever, thrombocytopenia and leukopenia. An isolate was derived from the blood of this patient during the course of diagnostic testing.
Lambert AJ, Velez JO, Brault AC, Calvert AE, Bell-Sakyi L, Bosco-Lauth AM, Staples JE, Kosoy OI.   +7 more
europepmc   +6 more sources

Widespread Circulation of Tick-Borne Viruses in Virginia—Evidence of Exposure to Heartland, Bourbon, and Powassan Viruses in Wildlife and Livestock [PDF]

Microorganisms
Emerging tick-borne viruses such as Powassan virus (POWV), Bourbon virus (BRBV), and Heartland virus (HRTV), whilst rare, can cause severe health problems in humans.
Ahmed Garba, Jennifer Riley, Kevin K. Lahmers, Gillian Eastwood   +3 more
doaj   +5 more sources

Indirect Evidence of Bourbon Virus (Thogotovirus, Orthomyxoviridae) Infection in North Carolina [PDF]

North Carolina Medical Journal, 2020
To the Editor—Bourbon virus (Thogotovirus, Orthomyxoviridae) was discovered in 2014 when a patient with history of multiple tick bites in Kansas died from an unknown infection [1].
N. Komar, N. Hamby, M. Palamar, J. E. Staples, Carl J. Williams   +4 more
semanticscholar   +4 more sources

Bourbon virus transmission, New York State [PDF]

medRxiv, 2022
In July 2019, Bourbon virus RNA was detected in an Amblyomma americanum tick removed from a resident of Long Island, New York. Tick infection and white-tailed deer (Odocoileus virginianus) serosurvey results demonstrate active transmission in New York ...
A. Dupuis, M. Prusinski, C. O’Connor, J. Maffei, C. A. Koetzner, T. E. Zembsch, S. Zink, A. L. White, M. Santoriello, C. Romano, G. Xu, F. Ribbe, S. Campbell, S. Rich, P. B. Backenson, L. Kramer, A. Ciota   +16 more
semanticscholar   +3 more sources