Establishment of duplex multi-enzyme isothermal rapid amplification detection method for bovine astrovirus and norovirus. [PDF]
Jiang L +5 more
europepmc +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
<i>Sarcoptes scabiei</i> Induces Discrete NET Release, Ca<sup>2+</sup> Fluxes and ROS Production Without Impairing Phagocytic Activity in Bovine Polymorphonuclear Neutrophils. [PDF]
Larrazabal C +5 more
europepmc +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Cysteine Supplementation During In Vitro Maturation Enhances Bovine Oocyte Developmental Competence Through Improved Redox Balance and Mitochondrial Function. [PDF]
Zhang X +7 more
europepmc +1 more source
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Detection and Genomic Characterization of Novel Respiratory Viruses in US and Mexican Cattle Farms. [PDF]
Oguzie JU +15 more
europepmc +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Receptor basis of unusual tissue tropism of avian influenza H5N1 clade 2.3.4.4b virus in cattle. [PDF]
Srinivas S +11 more
europepmc +1 more source

